RAGE Mediates a Novel Proinflammatory Axis A Central Cell Surface Receptor for S100/Calgranulin Polypeptides
- M. Hofmann, S. Drury, A. Schmidt
- BiologyCell
- 25 June 1999
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
- R. Deane, S. Yan, B. Zlokovic
- Biology, ChemistryNature Network Boston
- 29 June 2003
These findings suggest that vascular RAGE is a target for inhibiting pathogenic consequences of Aβ-vascular interactions, including development of cerebral amyloidosis.
Advanced glycation end products: sparking the development of diabetic vascular injury.
- Alison H. Goldin, J. Beckman, A. Schmidt, M. Creager
- BiologyCirculation
- 8 August 2006
Because of the emerging evidence about the adverse effects of AGEs on the vasculature of patients with diabetes, a number of different therapies to inhibit A GEs are under investigation.
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane that lines the circulatory system with its primary essential function being the maintenance of vessel wall permeability.…
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.
- S. Yan, X. Chen, A. Schmidt
- BiologyNature
- 1996
Evidence is presented that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia and indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.
Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases
- A. Taguchi, David C. Blood, A. Schmidt
- BiologyNature
- 18 May 2000
It is demonstrated that blockade of RAGE–amphoterin decreased growth and metastases of both implanted tumours and tumours developing spontaneously in susceptible mice.
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.
- M. Wautier, O. Chappey, S. Corda, D. Stern, A. Schmidt, J. Wautier
- BiologyAmerican Journal of Physiology. Endocrinology and…
- 1 May 2001
Findings underscore a central role of NADPH oxidase in AGE-RAGE-mediated generation of ROS and provide a mechanism for altered gene expression in A GE-related disorders.
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses.
- A. Schmidt, S. Yan, S. Yan, D. Stern
- BiologyJournal of Clinical Investigation
- 1 October 2001
These features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues.
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
- M. Neeper, A. Schmidt, A. Shaw
- BiologyJournal of Biological Chemistry
- 25 July 1992
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
- S. Yan, X. Chen, A. Schmidt
- BiologyNature
- 22 August 1996
Evidence is presented that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia and indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.
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