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DNA damage activates p53 through a phosphorylation-acetylation cascade.
It is suggested that DNA damage enhances p53 activity as a transcription factor in part through carboxy-terminal acetylation that, in turn, is directed by amino- terminal phosphorylation.
Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells.
Recombinant human HMGB1 elicits proinflammatory responses on endothelial cells and may contribute to alterations in endothelial cell function in human inflammation.
High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function.
Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins
It is demonstrated that most chromatin proteins have a high turnover on chromatin with a residence time on the order of seconds, that the major fraction of each protein is bound to chromatin at steady state, and that transient binding is a common property of chromatin-associated proteins.
Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins
- M. Bustin
- BiologyMolecular and Cellular Biology
- 1 August 1999
All the HMG proteins are considered to function as architectural elements that modify the structure of DNA and chromatin to generate a conformation that facilitates and enhances various DNA-dependent activities.
Dynamic binding of histone H1 to chromatin in living cells
The results support a model in which linker histones bind dynamically to chromatin in a stop-and-go mode, suggesting a higher rate of exchange upon chromatin remodelling.
High mobility group box‐1 protein induces the migration and activation of human dendritic cells and acts as an alarmin
- De Yang, Qian Chen, Huan Yang, K. Tracey, M. Bustin, J. Oppenheim
- BiologyJournal of leukocyte biology
- 1 January 2007
It is reported that HMGB1 simultaneously acts as a chemoattractant and activator of dendritic cells (DCs) and is considered to have the properties of an immune alarmin.
High mobility group protein-1 (HMG-1) is a unique activator of p53.
- L. Jayaraman, N. C. Moorthy, K. Murthy, J. Manley, M. Bustin, C. Prives
- Biology, ChemistryGenes & development
- 15 February 1998
HMG-1 promotes the assembly of higher order p53 nucleoprotein structures, and these data suggest that H MG-1 may activate p53 DNA binding by a novel mechanism involving a structural change in the target DNA.
HMG chromosomal proteins in development and disease.