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HIPK2 gene

Known as: homeodomain interacting protein kinase 2, HIPK2, HOMEODOMAIN-INTERACTING PROTEIN KINASE 2 
This gene plays a role in the phosphorylation of transcription factors.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Cycle ControlHIPK2 protein, humanPhosphorylationSerine/Threonine Phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
Many human diseases are characterized by the development of tissue hypoxia. Hypoxia-inducible factor (HIF) is a transcription… 
2010
2010
Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization
Review
2010
Review
2010
HIPK2--A therapeutical target to be (re)activated for tumor suppression: Role in p53 activation and HIF-1α inhibition
Oncosuppressor p53 is often inactivated by either mutations or deregulation of regulatory proteins. These include the homeodomain… 
2009
2009
HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage
Introduction/objectives:  The serine/threonine kinase homeodomain‐interacting protein kinase 2 (HIPK2) is a co‐regulator of an… 
2009
2009
The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4
HIPK2 is a eukaryotic Serine–Threonine kinase that controls cellular proliferation and survival in response to exogenous signals… 
2007
2007
Roscovitine‐activated HIP2 kinase induces phosphorylation of wt p53 at Ser‐46 in human MCF‐7 breast cancer cells
Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We… 
2007
2007
HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway
HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway 
Highly Cited
2004
Highly Cited
2004
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
The Pit1-Oct1-Unc86 domain (POU domain) transcription factor Brn3a controls sensory neuron survival by regulating the expression… 
2002
2002
HIPK2 associates with RanBPM.
2000
2000
Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.
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