FAQ

HIPK2 protein, human

Known as: homeodomain interacting protein kinase 2, human, Homeodomain-Interacting Protein Kinase 2, Homeodomain Interacting Protein Kinase 2 
Homeodomain-interacting protein kinase 2 (1198 aa, ~131 kDa) is encoded by the human HIPK2 gene. This protein plays a role in protein phosphorylation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
0519902017

Related topics

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14 relations

Broader (2)

Carrier ProteinsProtein-Serine-Threonine Kinases
Cell Cycle ControlCell NucleusEnzyme GeneHIPK2 gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
HIPK2 protein, human
Signal Transduction
Phosphotransferases
Cell Nucleus
Transcriptional Regulation
Phosphorylation

Papers overview

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2011
2011
Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.
Wnt pathways play essential roles in cell proliferation, morphogenesis, and cell fate specification during embryonic development… (More)
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2009
2009
Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.
Mutations in the methyl-CpG-binding protein 2 (MeCP2) are associated with Rett syndrome and other neurological disorders. MeCP2… (More)
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2008
2008
MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway.
The MUC1 oncoprotein interacts with the c-Abl tyrosine kinase and blocks nuclear targeting of c-Abl in the apoptotic response to… (More)
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2007
2007
Retraction: High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in human cancer, but the molecular basis… (More)
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Highly Cited
2006
Highly Cited
2006
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.
Sumoylation serves to control key cellular functions, but the regulation of SUMO E3 ligase activity is largely unknown. Here we… (More)
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2005
2005
Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification.
Homeodomain-interacting protein kinase 2 (HIPK2) is involved in transcriptional regulation, growth suppression, and apoptosis… (More)
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2005
2005
Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation.
Homeodomain-interacting protein kinase 2 (HIPK2) interacts with and phosphorylates various transcription factors that are… (More)
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Highly Cited
2003
Highly Cited
2003
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.
Here we demonstrate that endogenous human homeodomain-interacting protein kinase (HIPK) 2 and the highly homologous kinase HIPK3… (More)
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2001
2001
A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody.
Signal transduction from cell surface receptors to the nucleus is regulated in most part by protein phosphorylation. For the… (More)
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Highly Cited
1999
Highly Cited
1999
The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.
Transcriptional repression by sequence-specific DNA binding factors is mediated by the recruitment of a corepressor complex to… (More)
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