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HIPK2 protein, human

Known as: homeodomain interacting protein kinase 2, human, Homeodomain-Interacting Protein Kinase 2, Homeodomain Interacting Protein Kinase 2 
Homeodomain-interacting protein kinase 2 (1198 aa, ~131 kDa) is encoded by the human HIPK2 gene. This protein plays a role in protein phosphorylation… Expand
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Carrier ProteinsProtein-Serine-Threonine Kinases
Cell Cycle ControlCell NucleusEnzyme GeneHIPK2 gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
Persistent accumulation of misfolded proteins causes endoplasmic reticulum (ER) stress, a prominent feature in many… Expand
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Highly Cited
2013
Highly Cited
2013
The prolyl-isomerase Pin1 activates the mitochondrial death program of p53
In response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program… Expand
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Highly Cited
2011
Highly Cited
2011
Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2*
Wnt pathways play essential roles in cell proliferation, morphogenesis, and cell fate specification during embryonic development… Expand
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Review
2010
Review
2010
Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
p53 transcriptional activity depends mainly on posttranslational modifications and protein/protein interaction. Another important… Expand
Highly Cited
2006
Highly Cited
2006
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.
Sumoylation serves to control key cellular functions, but the regulation of SUMO E3 ligase activity is largely unknown. Here we… Expand
2006
2006
Transcriptional Activation of the SALL1 by the Human SIX1 Homeodomain during Kidney Development*
SALL1 is a member of the SAL gene family that encodes a group of putative developmental transcription factors. SALL1 plays a… Expand
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2005
2005
Desumoylation of homeodomain‐interacting protein kinase 2 (HIPK2) through the cytoplasmic‐nuclear shuttling of the SUMO‐specific protease SENP1
The modification of homeodomain‐interacting protein kinase 2 (HIPK2) by small ubiquitin‐like modifier 1 (SUMO‐1) plays an… Expand
2005
2005
Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.
The HIPK2 protein is a critical regulator of apoptosis and functionally interacts with p53 to increase gene expression. Here we… Expand
2002
2002
HIPK2 associates with RanBPM.
Using the yeast two-hybrid system, we have identified the Ran-binding protein (RanBPM) as an interaction partner of homeodomain… Expand
Highly Cited
1999
Highly Cited
1999
Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.
  • Y. Kim, C. Choi, Y. Kim
  • Proceedings of the National Academy of Sciences…
  • 1999
    • Corpus ID: 36198199
Posttranslational modifications such as ubiquitination and phosphorylation play an important role in the regulation of cellular… Expand
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