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HIC1 gene

Known as: HYPERMETHYLATED IN CANCER 1, ZNF901, ZBTB29 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
BACKGROUND Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in lung cancer metastasis. The class III deacetylase… 
Highly Cited
2008
Highly Cited
2008
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.
Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH… 
Highly Cited
2006
Highly Cited
2006
Hypermethylated RASSF1A in maternal plasma: A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis.
BACKGROUND We recently demonstrated that the promoter of the RASSF1A gene is hypermethylated in the placenta and hypomethylated… 
Review
2006
Review
2006
POZ for effect--POZ-ZF transcription factors in cancer and development.
Highly Cited
2006
Highly Cited
2006
Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early‐stage patients
Abstract:  The propensity of myelodysplastic syndrome (MDS) to transform into acute myeloid leukemia (AML) suggests the existence… 
Highly Cited
2005
Highly Cited
2005
Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer.
Highly Cited
2005
Highly Cited
2005
CpG island methylation of DNA damage response genes in advanced ovarian cancer.
We have determined the methylation frequencies of 24 CpG islands of genes associated with DNA damage responses or with ovarian… 
Highly Cited
2001
Highly Cited
2001
Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes.
Highly Cited
2000
Highly Cited
2000
Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.
HIC1 is a candidate tumor suppressor gene which is frequently hypermethylated in human tumors, and its location within the Miller… 
Highly Cited
1997
Highly Cited
1997
HIC1 hypermethylation is a late event in hematopoietic neoplasms.
HIC1, a candidate tumor suppressor gene on 17p13.3, is hypermethylated and silenced in a large number of solid tumors. To… 
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