CpG island methylation of DNA damage response genes in advanced ovarian cancer.

@article{Teodoridis2005CpGIM,
  title={CpG island methylation of DNA damage response genes in advanced ovarian cancer.},
  author={Jens M. Teodoridis and Jacqueline H. Hall and Sharon Marsh and Hilary D Kannall and Catriona Smyth and Jorge J Curto and Nadeem Ahmad Siddiqui and Hani Gabra and Ping Liao and Gordon Strathdee and Robert Brown},
  journal={Cancer research},
  year={2005},
  volume={65 19},
  pages={
          8961-7
        }
}
We have determined the methylation frequencies of 24 CpG islands of genes associated with DNA damage responses or with ovarian cancer in 106 stage III/IV epithelial ovarian tumors. We have analyzed this data for whether there is evidence of a CpG island methylator phenotype or associations of CpG island methylation with response to chemotherapy in advanced ovarian cancer. Frequent methylation was observed for OPCML, DCR1, RASSF1A, HIC1, BRCA1, and MINT25 (33.3%, 30.7%, 26.4%, 17.3%, 12.3%, and… CONTINUE READING

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