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Dynamics of global gene expression changes during mouse preimplantation development.
TLDR
A cascade of gene activation from maternal RNA/protein sets to zygotic genome activation and thence to MGA gene sets is proposed, which is a first step toward analysis of the complex gene regulatory networks. Expand
Age-associated alteration of gene expression patterns in mouse oocytes.
TLDR
A group of new oocyte-specific genes, members of the human NACHT, leucine-rich repeat and PYD-containing (NALP) gene family are identified and characterized, suggesting the existence of additional mechanisms for aging. Expand
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation.
TLDR
This study has identified candidate genes that provide a scope for in-depth analysis of their functions and an opportunity for examining their relevance to blastocyst dormancy and activation in numerous other species for which microarray analysis is not available or possible due to very limited availability of blastocysts. Expand
Gene expression changes at metamorphosis induced by thyroid hormone in Xenopus laevis tadpoles.
TLDR
Thyroid hormone controlled gene expression profiles have been studied in the tail, hind limb and brain tissues during TH-induced and spontaneous Xenopus laevis metamorphosis and some of these same energy metabolism-related genes are up-regulated in the limb andbrain programs by TH. Expand
Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice
TLDR
Altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk, as seen in the normal colonic mucosa of humans with LOI. Expand
Dissecting Oct3/4-Regulated Gene Networks in Embryonic Stem Cells by Expression Profiling
TLDR
The findings suggest that the global expression profiling of gene-manipulated ES cells can help to delineate the structure and dynamics of gene regulatory networks. Expand
Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.
TLDR
A role for Hic1 in the development of structures affected in the Miller-Dieker syndrome is demonstrated, and functional evidence is provided to strengthen its candidacy as a gene involved in this disorder. Expand
An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells.
TLDR
The results show the presence of different types or states of cells within ES cell cultures otherwise thought to be undifferentiated and homogeneous, suggesting a previously unappreciated complexity inES cell cultures. Expand
High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
TLDR
A chamber system that allows parallel processing of embryos without the aid of a microscope is developed that provides a useful tool to a systematic genome-scale analysis of preimplantation embryos. Expand
Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation
TLDR
It is concluded that Jak/Stat3 activity plays a fundamental role to promote pluripotency establishment at the epigenetic level, by facilitating DNA demethylation/de novo methylation, and open‐chromatin formation during late‐stage reprogramming. Expand
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