HERC2 gene

Known as: HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 2 Gene, HECT DOMAIN AND RCC1-LIKE DOMAIN 2, p528 
This gene is involved in both protein ubiquitination and DNA damage repair.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Pigmentation of skin, eye, and hair reflects some of the most evident common phenotypes in humans. Several candidate genes for… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid (DNA) double-strand breaks (DSBs) by the RNF8/RNF168… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Cisplatin is one of the most commonly used anticancer drugs. It kills cancer cells by damaging their DNA, and hence cellular DNA… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage1–9… (More)
Is this relevant?
2010
2010
The breast cancer suppressor BRCA1 forms a stable heterodimeric E3 ubiquitin ligase with BARD1. Each protein controls the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Despite the recent rapid growth in genome-wide data, much of human variation remains entirely unexplained. A significant… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
We have previously demonstrated that haplotypes of three single nucleotide polymorphisms (SNPs) within the first intron of the… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Human iris color was one of the first traits for which Mendelian segregation was established. To date, the genetics of iris color… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Highly Cited
2007
Highly Cited
2007
The human eye color is a quantitative trait displaying multifactorial inheritance. Several studies have shown that the OCA2 locus… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
2000
2000
Recombination between chromosome-specific low-copy repeats (duplicons) is an underlying mechanism for several genetic disorders… (More)
Is this relevant?