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HAND2 gene

Known as: HAND2, bHLHa26, Thing2 
This gene plays a role in both transcriptional regulation and cardiac development.
National Institutes of Health

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HAND2 wt Allele
Heart- and Neural Crest Derivatives-Expressed Protein 2Homo sapiensOrganogenesisTranscriptional Regulation

Papers overview

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2012
2012
A Phox2- and Hand2-Dependent Hand1 cis-Regulatory Element Reveals a Unique Gene Dosage Requirement for Hand2 during Sympathetic Neurogenesis
Neural crest cell specification and differentiation to a sympathetic neuronal fate serves as an important model for neurogenesis… 
2007
2007
Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type
The noradrenergic cell type is characterized by the expression of proteins involved in the biosynthesis, transport, and secretion… 
2004
2004
Cooperative Interaction between the Basic Helix-loop-helix Transcription Factor dHAND and Myocyte Enhancer Factor 2C Regulates Myocardial Gene Expression*
Cardiac-restricted transcription factors dHAND and myocyte enhancer factor 2C are expressed in the developing heart and activate… 
Highly Cited
2003
Highly Cited
2003
HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a.
Highly Cited
2003
Highly Cited
2003
The Interaction between dHAND and Arix at the Dopamine β-Hydroxylase Promoter Region Is Independent of Direct dHAND Binding to DNA*
Dopamine β-hydroxylase (DBH) catalyzes the production of norepinephrine, and its expression defines the noradrenergic phenotype… 
2002
2002
Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene.
The helix-loop-helix transcription factor HAND2 plays a vital role in the development of the heart, limb, facies, and other… 
2001
2001
Human eHAND, but not dHAND, is down-regulated in cardiomyopathies.
The progression of cardiomyopathy to congestive heart failure is often associated with the expression of fetal cardiac-specific… 
Highly Cited
1999
Highly Cited
1999
Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors
The basic helix‐loop‐helix transcription factors eHAND and dHAND are involved in developmental cardiac growth and differentiation… 
Review
1999
Review
1999
Developmental and genetic aspects of congenital heart disease.
Congenital heart defects (CHDs) are the result of abnormal cardiac mesoderm or cardiac neural crest development. The molecular… 
1997
1997
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