Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type

@article{Rychlik2005Phox2AD,
  title={Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type},
  author={Jennifer L. Rychlik and Marlene M Hsieh and Lee E. Eiden and Elaine J. Lewis},
  journal={Journal of Molecular Neuroscience},
  year={2005},
  volume={27},
  pages={281-292}
}
The noradrenergic cell type is characterized by the expression of proteins involved in the biosynthesis, transport, and secretion of noradrenaline and is dependent on the sequential and combinatorial expression of numerous transcription factors, including Phox2a, Phox2b, dHAND, GATA2, GATA3, and MASH1. Phox2a and Phox2b transactivate the promoter of the gene encoding the noradrenergic biosynthetic enzyme, dopamine β-hydroxylase (DBH), and dHAND potentiates the activity of Phox2a. In this study… CONTINUE READING
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Specification of the central noradrenergic phenotype by the homeobox gene Phox2b

  • A. Pattyn, C. Goridis, J F.Brunet
  • Mol. Cell. Neurosci
  • 2002
Highly Influential
4 Excerpts

Molecular cloning and characterization of the promoter region of the human Phox2b gene

  • S. Jong Hong, H. Chae, K S.Kim
  • Brain Res. Mol. Brain Res
  • 2004

The interaction between dHAND and Arix at the dopamine betahydroxylase promoter region is independent of direct dHAND binding to DNA

  • L RychlikJ., V. Gerbasi, E J.Lewis
  • J. Biol
  • 2003

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