Guanine Nucleotides

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its… Expand

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal… Expand

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of… Expand

Plant receptor-like kinases (RLKs) are involved in nearly all aspects of plant life including growth, development and stress… Expand

Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to… Expand

Guanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various… Expand

Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells… Expand

Signaling pathways that link extracellular factors to activation of the monomeric guanosine triphosphatase (GTPase) Rho control… Expand

A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… Expand

THE fungal metabolite brefeldin A is a powerful tool for investigating membrane traffic in eukaryotic cells1. The effects of… Expand