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Guanine Nucleotide-Binding Protein G(q) Subunit Alpha

Known as: G(q) Alpha, G-ALPHA-q, Guanine Nucleotide-Binding Protein Alpha-Q 
Guanine nucleotide-binding protein G(q) subunit alpha (353 aa, ~41 kDa) is encoded by the human GNAQ gene. This protein may play a role in… 
National Institutes of Health

Related topics

Related topics

20 relations
Angiotensin II Signaling PathwayCCR5 Signaling PathwayCXCR4 Signaling PathwayCalcineurin Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Gaq proteins: molecular pharmacology and therapeutic potential
Seven transmembrane G protein-coupled receptors (GPCRs) have gained much interest in recent years as it is the largest class… 
2013
2013
Arginine Vasopressin Enhances Cell Survival via a G Protein–Coupled Receptor Kinase 2/β-Arrestin1/Extracellular-Regulated Kinase 1/2–Dependent Pathway in H9c2 Cells
Circulating levels of arginine vasopressin (AVP) are elevated during hypovolemia and during cardiac stress. AVP activates… 
Highly Cited
2012
Highly Cited
2012
The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma
GNAQ mutations at codon 209 have been recently identified in approximately 50% of uveal melanomas (UM) and are reported to be… 
Review
2011
Review
2011
Therapeutic Implications of the Emerging Molecular Biology of Uveal Melanoma
Uveal melanoma represents the most common primary intraocular malignancy in adults. Although uveal and cutaneous melanomas both… 
Highly Cited
2008
Highly Cited
2008
Regulation of Serotonin Biosynthesis by the G Proteins Gαo and Gαq Controls Serotonin Signaling in Caenorhabditis elegans
To analyze mechanisms that modulate serotonin signaling, we investigated how Caenorhabditis elegans regulates the function of… 
Highly Cited
2005
Highly Cited
2005
Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins
Highly Cited
2000
Highly Cited
2000
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Targeted cardiac overexpression of the alpha-subunit of the heterotrimeric G protein G(q) in transgenic mice evokes hypertrophy… 
1999
1999
Kinetic control of guanine nucleotide binding to soluble Gαq
Highly Cited
1998
Highly Cited
1998
The Cyclosporin A-sensitive Nuclear Factor of Activated T Cells (NFAT) Proteins Are Expressed in Vascular Smooth Muscle Cells
Expression of the antigen-regulated, cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) is not restricted to… 
Highly Cited
1997
Highly Cited
1997
Platelet signal transduction defect with Gα subunit dysfunction and diminished Gαq in a patient with abnormal platelet responses
G proteins play a major role in signal transduction upon platelet activation. We have previously reported a patient with impaired… 
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