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Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
TLDR
The data reveal a major role for perilipin in adipose lipid metabolism and suggest perilipIn as a potential target for attacking problems associated with obesity.
Functional Conservation for Lipid Storage Droplet Association among Perilipin, ADRP, and TIP47 (PAT)-related Proteins in Mammals,Drosophila, and Dictyostelium *
TLDR
It is shown that GFP-tagged TIP47 co-localizes with isolated intracellular lipid droplets and that related proteins from species as diverse as Drosophila and Dictyostelium can also target mammalian or Drosophile lipid droplet surfaces in vivo, strongly indicating that they have a common function for lipid deposition and/or mobilization.
Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis*
TLDR
It is concluded that perilipin A increases the triacylglycerol content of cells by forming a barrier that reduces the access of soluble lipases to stored lipids, thus inhibiting triacyLglycersol hydrolysis.
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells.
TLDR
The properties, distribution, localization, and potential functions of perilipins and ADRP, as well as those of vimentin and the recently-described 'capsular' proteins, in lipid storage and metabolism are discussed.
A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system.
TLDR
A robust system for the production of multiple gene mutations in Dictyostelium is described by recycling a single selectable marker, Blasticidin S resistance, using the Cre-loxP system and confirmed by generating a single cell carrying four separate gene disruptions.
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
TLDR
It is shown that HSL is basally associated with lipid droplet surfaces at a low level in perilipin nulls, but that stimulated translocation from the cytosol to lipid droplets is absent in adipocytes derived from embryonic fibroblasts of perilip in-null mice.
On the Control of Lipolysis in Adipocytes
TLDR
The participation of perilipin A is indicated by the findings that this protein can protect neutral lipids within droplets from hydrolysis, but active participation in the lipolytic reaction is yet to be proved.
Structure of a lipid droplet protein; the PAT family member TIP47.
TLDR
The crystal structure of the C-terminal portion of TIP47 suggests an analogy between PAT proteins and apolipoproteins in which helical repeats interact with lipid while the ordered C-Terminal region is involved in protein:protein interactions.
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins
TLDR
Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially, in a unifying nomenclature for the gene and protein family members.
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets
TLDR
Diversity of Plin function is suggested, previous assumptions about shared collective actions of the Plins are altered, and each Plin can have separate and unique functions are altered.
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