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Maternal obesity affects offspring weight, body composition, and organ function, increasing diabetes and metabolic syndrome risk. We determined effects of maternal obesity and a high-energy diet on fetal pancreatic development. Sixty days prior to breeding, ewes were assigned to control [100% of National Research Council (NRC) recommendations] or obesogenic(More)
Senescence is accompanied by oxidative stress and cardiac dysfunction, although the link between the two remains unclear. This study examined the role of antioxidant metallothionein on cardiomyocyte function, superoxide generation, the oxidative stress biomarker aconitase activity, cytochrome c release, and expression of oxidative stress-related proteins,(More)
OBJECTIVE Development of brown-like/beige adipocytes in white adipose tissue (WAT) helps to reduce obesity. Thus we investigated the effects of resveratrol, a dietary polyphenol capable of preventing obesity and related complications in humans and animal models, on brown-like adipocyte formation in inguinal WAT (iWAT). METHODS CD1 female mice (5-month(More)
0 Introduction Let (M,g) be a compact Riemannian manifold of dimension n (n ≥ 3) with smooth boundary. In [LZ], we established some sharp trace inequality on (M,g). In this paper we establish some sharp Sobolev inequalities using the method in [LZ]. For n ≥ 3, it was shown by Aubin [Au1] and Talenti [T] that, for p = 2n/(n− 2), 1 S1 = inf { ∫ Rn |∇u|2 ( ∫(More)
BACKGROUND/AIM Recent evidence suggests that endoplasmic reticulum (ER) stress provoked under diabetic conditions augments the expression of scavenger receptors on macrophages, promoting the uptake of oxidized low-density lipoprotein uptake and atherogenesis. The aim of the present study was to test the hypothesis that the chemical chaperone(More)
The ubiquitous nature of Listeria monocytogenes and its ability to grow at refrigerated temperature makes L. monocytogenes a significant threat to the safety of ready-to-eat (RTE) meat products. The contamination by L. monocytogenes in RTE meat primarily occurs during slicing and packaging after cooking. The effectiveness of postpackage decontamination(More)
In this note, we present some Hardy type inequalities for functions which do not vanish on the boundary of a given domain. We establish these inequalities for both bounded and unbounded domains and also obtain the best embedding constants in these inequalities for special domains. Our results are motivated by and building upon some recent work in [5, 6, 9,(More)
Article history: Received 25 April 2011 Received in revised form 7 September 2011 Accepted 9 September 2011 Available online xxxx Verifying high-resolution forecasts is challenging because forecasts can be considered good by their end-users even when there is no pixel-to-pixel correspondence between the forecast and the verification fields. Many of the(More)