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Glutethimide

Known as: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, 2-Ethyl-2-phenylglutarimide, Glutethimide [Chemical/Ingredient] 
A hypnotic and sedative. Its use has been largely superseded by other drugs.
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (6)

4-hydroxyglutethimideDoridenNoxironcyclohexylaminoglutethimide
Drug AllergyGlutethimide:MCnc:Pt:Gast fld:QnGlutethimide:MCnc:Pt:Ser/Plas:QnGlutethimide:SCnc:Pt:Urine:Qn

Broader (5)

HypnoticsHypnotics and SedativesPiperidonesSedatives

Papers overview

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1985
1985
Deaths as a result of a combination of codeine and glutethimide.
Toxicological findings are described in 16 medical examiner cases directly related to the combination of codeine and glutethimide… 
1981
1981
N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs II: possible prodrugs of allopurinol, glutethimide, and phenobarbital.
Solid samples of 1-hydroxymethyl- and 1,5-dihydroxymethylallopurinol, 1-hydroxymethylglutethimide, and 1… 
1979
1979
Correlates of outcome following acute glutethimide overdosage.
Potential predictors of outcome following acute glutethimide overdosage were assessed in 63 patients hospitalized with this… 
1975
1975
Synthesis of an active hydroxylated glutethimide metabolite and some related analogs with sedative-hypnotic and anticonvulsant properties.
Two synthetic pathways are described for the preparation of 4-hydroxy-2-ethyl-2-phenylglutarimide (2), an active hydroxylated… 
1973
1973
Dimethylformamide dimethylacetal as a derivatizing agent for GLC of barbiturates and related compounds.
Dimethylformamide dimethylacetal reacted quantitatively and reproducibly with glutethimide, phenobarbital, hexobarbital… 
1972
1972
A rapid micro-method for the screening and measurement of barbiturates and related compounds in plasma by gas-liquid chromatography
A rapid gas-chromatographic method has been developed for the determination of butobarbitone, amylobarbitone, hexabarbitone… 
1971
1971
A gas-chromatographic method for separating and measuring barbiturates and glutethimide in blood.
A gas-chromatographic method is described for the quantitative determination of 11 barbiturates and glutethimide in blood. The… 
Highly Cited
1970
Highly Cited
1970
Stimulation of adrenal cholesterol uptake from plasma by adrenocorticotrophin.
The effect of ACTH on adrenal cholesterol accumulation was examined in the rat. Hypophysectomized rats treated with ACTH… 
1958
1958
Acute glutethimide (Doriden) poisoning; the use of bemegride (Megimide) and hemodialysis.
Glutethimide (Doriden)* has had an unusually rapid and widespread introduction into clinical medicine as a hypnotic and sedative… 
1958
1958
Addiction to glutethimide (doriden).
This report illustrates one case where a potent, new, non-barbiturate sedative (glutethimide) proved to be addicting to a…