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Glutamate Carboxypeptidase II

Known as: Hydrolase I, Folate, Dipeptidase, N-Acetylated-alpha-Linked Acidic, N-Acetylaspartylglutamate Peptidase 
A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Antigens, NeoplasmDipeptidasesSurface Antigens
FOLH1 wt AlleleIn BloodProcess of secretionantagonists & inhibitors

Narrower (1)

glutamate carboxypeptidase II, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
T2 relaxation time abnormalities in bipolar disorder and schizophrenia
There are substantial abnormalities in the number, density, and size of cortical neurons and glial cells in bipolar disorder and… 
Highly Cited
2008
Highly Cited
2008
Phencyclidine and Dizocilpine Induced Behaviors Reduced by N-acetylaspartylglutamate Peptidase Inhibition via Metabotropic Glutamate Receptors
Review
2006
Review
2006
Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.
GCP II inhibition decreases extracellular excitotoxic glutamate and increases extracellular NAAG, both of which provide… 
Highly Cited
2001
Highly Cited
2001
Generation of xylose solutions from Eucalyptus globulus wood by autohydrolysis-posthydrolysis processes: posthydrolysis kinetics.
Highly Cited
1996
Highly Cited
1996
Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor.
1. We investigated the glutamate-mediated modulation of voltage-activated calcium currents in cultured interneurons of the… 
Highly Cited
1987
Highly Cited
1987
Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.
Highly Cited
1984
Highly Cited
1984
The phosphorylcholine acceptor in the phosphatidylcholine:ceramide cholinephosphotransferase reaction. Is the enzyme a transferase or a hydrolase?
1983
1983
Conformation of 2‐aminofluorene‐modified DNA
Minimized potential‐energy calculations were performed to determine the conformation of the 2‐aminofluorene (AF) adduct to dCpdG… 
1977
1977
Biochemical characteristics, metabolism, and antitumor activity of several acetylated hexosamines.
We have synthesized several potential inhibitors and/or modifiers of the carbohydrate portion of plasma membrane glycoconjugates… 
Highly Cited
1971
Highly Cited
1971
Mass spectrometry of neutral, mono- and disialoglycosphingolipids.
Microgram quantities of complex glycosphingolipids were fully trimethylsilylated and analyzed by mass spectrometry. Reproducible… 
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