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glutamate carboxypeptidase II, human

Known as: PSMA antigen, Glutamate Carboxypeptidase II, Prostate-Specific Membrane Antigen 
Glutamate carboxypeptidase 2 (750 aa, ~84 kDa) is encoded by the human FOLH1 gene. This protein plays a role in the mediation of folate metabolism.
National Institutes of Health

Related topics

Related topics

13 relations
Enzyme GeneFOLH1 geneFOLH1 wt AlleleHydrolysis

Broader (2)

Glutamate Carboxypeptidase IISurface Antigens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Correlation Between SUVmax and CT Radiomic Analysis Using Lymph Node Density in PET/CT-Based Lymph Node Staging
In patients with lung cancer (LC), malignant melanoma (MM), gastroenteropancreatic neuroendocrine tumors (GEP NETs), and prostate… 
Highly Cited
2016
Highly Cited
2016
An improved synthesis of the radiolabeled prostate-specific membrane antigen inhibitor, [(18) F]DCFPyL.
The radiosynthesis of [(18) F]DCFPyL on 2 distinct automated platforms with full regulatory compliant quality control… 
Highly Cited
2013
Highly Cited
2013
Sub-nanomolar detection of prostate-specific membrane antigen in synthetic urine by synergistic, dual-ligand phage.
The sensitive detection of cancer biomarkers in urine could revolutionize cancer diagnosis and treatment. Such detectors must be… 
Highly Cited
2012
Highly Cited
2012
Virus-polymer hybrid nanowires tailored to detect prostate-specific membrane antigen.
We demonstrate the de novo fabrication of a biosensor, based upon virus-containing poly(3,4-ethylene-dioxythiophene) (PEDOT… 
Highly Cited
2007
Highly Cited
2007
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
Inhibition of glutamate carboxypeptidase II (GCPII) has been shown to be neuroprotective in multiple preclinical models in which… 
Highly Cited
2007
Highly Cited
2007
Production of Multimeric Prostate-Specific Membrane Antigen Small-Molecule Radiotracers Using a Solid-Phase 99mTc Preloading Strategy
Small-molecule ligands specific for prostate-specific membrane antigen (PSMA) have the potential to improve prostate cancer… 
2007
2007
Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.
Human glutamate carboxypeptidase II (GCPII) occurs in the central nervous system as well as in human prostate (where it is called… 
Highly Cited
2002
Highly Cited
2002
Preoperative combined nested reverse transcriptase polymerase chain reaction for prostate-specific antigen and prostate-specific membrane antigen does not correlate with pathologic stage or…
PURPOSE We report a prospective study examining the ability of preoperative nested reverse transcriptase polymerase chain… 
Review
2000
Review
2000
Voice over IP signaling: H.323 and beyond
Signaling has been one of the key areas of Voice over IP (VoIP) technologies since inception. H.323 was the key protocol that… 
Highly Cited
1998
Highly Cited
1998
Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line.
An alternatively spliced variant of prostate-specific membrane antigen (PSMA) designated PSM' was originally described following… 
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