glutamate carboxypeptidase II, human

Known as: PSMA antigen, Glutamate Carboxypeptidase II, Prostate-Specific Membrane Antigen 
Glutamate carboxypeptidase 2 (750 aa, ~84 kDa) is encoded by the human FOLH1 gene. This protein plays a role in the mediation of folate metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
010020019892017

Papers overview

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Highly Cited
2013
Highly Cited
2013
Positron emission tomography (PET) with choline tracers has found widespread use for the diagnosis of prostate cancer (PC… (More)
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Highly Cited
2009
Highly Cited
2009
Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been targeted with RNA aptamer–small interfering… (More)
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Highly Cited
2008
Highly Cited
2008
Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its… (More)
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Highly Cited
2008
Highly Cited
2008
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and… (More)
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2007
2007
Glutamate carboxypeptidase II (GCPII) is a transmembrane glycoprotein expressed in various tissues. When expressed in the brain… (More)
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Highly Cited
2004
Highly Cited
2004
Nucleic acid ligands (aptamers) are potentially well suited for the therapeutic targeting of drug encapsulated controlled release… (More)
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Highly Cited
2002
Highly Cited
2002
We have identified two synthetic oligonucleotides (aptamers) that bind to prostate cancer cells,with low nanomolar affinity, via… (More)
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1998
1998
Jejunal folylpoly-gamma-glutamate carboxypeptidase hydrolyzes dietary folates prior to their intestinal absorption. The complete… (More)
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Highly Cited
1997
Highly Cited
1997
Prostate-specific membrane antigen is a type II membrane protein with folate hydrolase activity produced by prostatic epithelium… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVES To determine the expression of prostate-specific membrane antigen (PSMA) before and after androgen-deprivation therapy… (More)
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