J. Lubkowski

Publications250
h-index48
Citations8,065
Highly Influential Citations336
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Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
TLDR
It appears that mammalian antimicrobial proteins contribute to both innate and adaptive antimicrobial immunity, as several defensins have considerable immunoenhancing activity.
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis.
TLDR
The approach presented here simplifies the production of proteins from a wide variety of organisms for genomics-based studies and automates the design of oligonucleotides for gene synthesis.
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
TLDR
Similar to defensins, CCL20/MIP-3alpha has antimicrobial effects on Escherichia coli, Pseudomonas aeruginosa, Moraxella catarrhalis, Streptococcus pyogenes, Enterococcus faecium, Staphylococcus aureus, and Candida albicans.
Many chemokines including CCL20/MIP‐3α display antimicrobial activity
TLDR
Similar to defensins, CCL20/MIP‐3α has antimicrobial effects on Escherichia coli, Pseudomonas aeruginosa, Moraxella catarrhalis, Streptococcus pyogenes, Enterococcus faecium, Staphylococcus aureus, and Candida albicans.
The Structure of Human β-Defensin-2 Shows Evidence of Higher Order Oligomerization*
TLDR
The structural and electrostatic properties of the hBD2 octamer support an electrostatic charge-based mechanism of membrane permeabilization by β-defensins, rather than a mechanism based on formation of bilayer-spanning pores.
Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.
Human alpha-defensins block papillomavirus infection.
TLDR
Screening for compounds that might function as inhibitors of HPV infection revealed that human alpha-defensins 1-3 and HD-5 are potent antagonists of infection by both cutaneous and mucosal papillomavirus types, with emphasis on human peptides previously implicated in innate antimicrobial immunity.
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3
TLDR
It is found that human β-defensin 3 (hBD3), a recently described member of the growing β family, did not fold preferentially into a native conformation in vitro under various oxidative conditions, demonstrating that disulfide bonding in hBD3 is fully dispensable for its antimicrobial function.
Human beta-defensins.
TLDR
This review presents some recent advances in the studies of human beta-defensins, with an emphasis on possible correlations between their structural and functional properties.
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
TLDR
It is found that MIP-3alpha possesses antibacterial activity of greater potency than human beta-defensin-1 and -2 against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213, while having no activity against the fungus Candida albicans.
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