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Gene Transfer

Incorporation of new DNA into an organism's cells, usually by a vector such as a modified virus. Used in gene therapy.(From Human Genome Project… 
National Institutes of Health

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gene therapy

Papers overview

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Highly Cited
1998
Highly Cited
1998
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Both retro- and adenovirus-mediated gene therapy have been suggested as a novel approach to the treatment of malignant brain… 
Highly Cited
1998
Highly Cited
1998
Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system
Baculovirus vectors are efficient tools for gene transfer into hepatocytes in vitro. However, gene transfer is strongly reduced… 
Highly Cited
1997
Highly Cited
1997
Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer.
Today, nonviral gene transfer vectors attract more attention as a therapeutic strategy for human diseases, because viral vectors… 
Highly Cited
1995
Highly Cited
1995
FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer.
Despite good initial success in vivo, gene transfer using first-generation replication-defective adenovirus has been reported to… 
Highly Cited
1994
Highly Cited
1994
Gene transfer with a series of lipophilic DNA-binding molecules.
Synthetic gene transfer vectors could be an attractive alternative to biological vehicles for gene therapy. In an effort to… 
Highly Cited
1992
Highly Cited
1992
Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats
Intracerebral grafts consisting of primary fibroblasts genetically engineered to express NGF were used to assess the regenerative… 
Highly Cited
1989
Highly Cited
1989
Expression of functional nerve growth factor receptors after gene transfer.
Nerve growth factor (NGF) interacts with both high affinity (Kd = 10(-10)-10(-11)M) and low affinity (Kd = 10(-8)-10(-9)M… 
Highly Cited
1988
Highly Cited
1988
Gene Transfer into Sheep
Gene transfer into animals has considerable potential for livestock improvement. If this potential is to be realized, the ease of… 
Highly Cited
1987
Highly Cited
1987
Direct gene transfer into human cultured cells facilitated by laser micropuncture of the cell membrane.
The selective alteration of the cellular genome by laser microbeam irradiation has been extensively applied in cell biology. We… 
Highly Cited
1980
Highly Cited
1980
A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces
Selectable plasmid vectors that contain a gene encoding resistance to the antibiotic methylenomycin A and that are suitable for… 
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