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Viable offspring derived from fetal and adult mammalian cells
Nature 385, 810-813(1997). In this Letter in the 27 February issue, a production error led to the image for part b of Fig. 1 (fetal fibroblasts) being used twice, as parts b and c. The correct imageExpand
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Viable offspring derived from fetal and adult mammalian cells
Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up theExpand
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Sheep cloned by nuclear transfer from a cultured cell line
NUCLEAR transfer has been used in mammals as both a valuable tool in embryological studies1 and as a method for the multiplication of 'elite' embryos2–4. Offspring have only been reported when earlyExpand
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Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts.
Ovine primary fetal fibroblasts were cotransfected with a neomycin resistance marker gene (neo) and a human coagulation factor IX genomic construct designed for expression of the encoded protein inExpand
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Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2RExpand
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Cell cycle co-ordination in embryo cloning by nuclear transfer.
Exciting new opportunities in embryo cloning have been made possible by recent studies on the interaction of the donor nucleus with the recipient cytoplasm after embryo reconstruction. This articleExpand
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Large offspring syndrome in cattle and sheep.
Bovine and ovine embryos exposed to a variety of unusual environments prior to the blastocyst stage have resulted in the development of unusually large offspring which can also exhibit a number ofExpand
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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-TDP). IdentificationExpand
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Somatic cell nuclear transfer
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure thatExpand
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Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
Glial proliferation and activation are associated with disease progression in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia. In this study, we describe a unique platform toExpand
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