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Biology of vascular endothelial growth factors
TLDR
The biology of VEGFs is reviewed and their role in pathological angiogenesis and lymphangiogenesis is evaluated. Expand
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor
TLDR
It is found that isolated human primary lymphatic and blood vascular endothelial cells show interesting differences in gene expression relevant for their distinct functions in vivo, and overexpression of the homeobox transcription factor Prox‐1 in the BECs is suggested to act as a cell proliferation inducer and a fate determination factor for the LECs. Expand
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
TLDR
The data show that Foxc2 is essential for the morphogenesis of lymphatic valves and the establishment of a pericyte-free lymphatic capillary network and that it cooperates with Vegfr3 in the latter process. Expand
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
TLDR
It is demonstrated that VEGFR-3 is highly expressed in angiogenic sprouts, and genetic targeting or blocking of VEG FR-3 signalling with monoclonal antibodies results in decreased sprouting, vascular density, vessel branching and endothelial cell proliferation in mouse angiogenesis models, implicate VEGfr-3 as a regulator of vascular network formation. Expand
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
TLDR
It is suggested that when lymphangiogenesis is impaired, airway inflammation may lead to bronchial lymphedema and exaggerated airflow obstruction, and Correction of defective lymphang iogenesis may benefit the treatment of asthma and other inflammatory airway diseases. Expand
A model for gene therapy of human hereditary lymphedema
TLDR
By using virus-mediated VEGF-C gene therapy, the results suggest that growth factor gene therapy is applicable to human lymphedema and provide a paradigm for other diseases associated with mutant receptors. Expand
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
TLDR
It is suggested that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGf-C and its receptor. Expand
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
TLDR
It is shown that a soluble form of VEGFR-3 is a potent inhibitor of Vascular endothelial growth factor (VEGF)-C and VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal. Expand
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
TLDR
A molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development is provided and show that forkhead transcription factor Foxc2 controls this process. Expand
Low density lipoprotein undergoes oxidative modification in vivo.
TLDR
Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera. Expand
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