Gene Frequency

Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies… Expand

Sequencing of circulating tumor DNA from cancer patients is a cost-efficient approach with turnaround time compatible with… Expand

Genetic predisposition to obesity presents a paradox: how do genetic variants with a detrimental impact on human health persist… Expand

The increasing affordability of sequencing and genotyping technologies has transformed the field of molecular ecology in recent… Expand

Similar to parasites, malignant cells exploit the host for energy, resources and protection, thereby impairing host health and… Expand

mtDNA is a multicopy genome. When mutations exist, they can affect a varying proportion of the mtDNA present within every cell… Expand

Population stratification—allele frequency differences between cases and controls due to systematic ancestry differences—can… Expand

We describe extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data. Most… Expand

We describe a model-based clustering method for using multilocus genotype data to infer population structure and assign… Expand

The magnitudes of the systematic biases involved in sample heterozygosity and sample genetic distances are evaluated, and… Expand