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A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
TLDR
Case-control analyses showed that a six-nucleotide deletion in the CASP8 promoter is associated with reduced susceptibility to multiple cancers, including lung, esophageal, gastric, colorectal, cervical and breast cancers, acting in an allele dose–dependent manner.
Identification of genomic alterations in oesophageal squamous cell cancer
TLDR
Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking, and novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC are explored.
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.
TLDR
Findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer.
Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer.
TLDR
It is found that genetic polymorphisms influencing T-cell activation modify cancer susceptibility, and the 49G>A polymorphism in the CTLA-4 leading sequence causing (17)Ala to ( 17)Thr amino acid substitution is associated with increased susceptibility to multiple cancers, including lung, breast, esophagus, and gastric cardia cancers.
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
TLDR
Results suggest that genetic variants in 3q28, 5p15.33, 13q 12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese.
Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer
TLDR
In conclusion, genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 contribute to the risk of developing lung cancer.
Circulating MicroRNAs, miR‐21, miR‐122, and miR‐223, in patients with hepatocellular carcinoma or chronic hepatitis
TLDR
Serum miRNAs presented in serum of patients with HCC and chronic hepatitis have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC, according to Receiver‐operator characteristic (ROC) curve analyses.
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma
TLDR
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, a genome-wide association study in 2,514 chronic HBV carriers followed by a 2-stage validation among 6 independent populations of chronicHBV carriers showed that HCC risk was significantly associated with two independent loci.
A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer
TLDR
The results showed that the functional SNP −77T>C in XRCC1 5′UTR was associated with cancer development owing to the decreased transcriptional activity of C-allele-containing promoter with higher affinity to Sp1 binding.
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
TLDR
The findings provide evidence that the 1p36.22 locus confers susceptibility to HBV-related HCC, and suggest that KIF1B-, UBE4B- or PGD-related pathways might be involved in the pathogenesis of this malignancy.
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