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Galectin 3

Known as: Antigen, Macrophage-2, L-34, Mac-2 Antigen 
A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ… Expand
National Institutes of Health

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Galectin 3 AntigenLGALS3 protein, human
In BloodLGALS3 geneProcess of secretionagonists
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Papers overview

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Review
2018
Review
2018
Galectin-3 and cancer stemness
Over the last few decades galectin-3, a carbohydrate binding protein, with affinity for N-acetyllactosamine residues, has been… Expand
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Review
2018
Review
2018
Role of Galectins in Tumors and in Clinical Immunotherapy
Galectins are glycan-binding proteins that contain one or two carbohydrate domains and mediate multiple biological functions. By… Expand
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Highly Cited
2011
Highly Cited
2011
Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction
Abstract Aims. Galectin-3 is an emerging biomarker which has been studied in relatively small heart failure (HF) cohorts with… Expand
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Highly Cited
2006
Highly Cited
2006
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Central to fibrogenesis and the scarring of organs is the activation of fibroblasts into matrix-secreting myofibroblasts. We… Expand
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Highly Cited
2006
Highly Cited
2006
Galectin-3 and Galectin-1 Bind Distinct Cell Surface Glycoprotein Receptors to Induce T Cell Death1
Galectins are a family of mammalian β-galactoside-binding proteins that positively and negatively regulate T cell death… Expand
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Highly Cited
2004
Highly Cited
2004
Galectin-3 Marks Activated Macrophages in Failure-Prone Hypertrophied Hearts and Contributes to Cardiac Dysfunction
Background—Inflammatory mechanisms have been proposed to be important in heart failure (HF), and cytokines have been implicated… Expand
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Highly Cited
2004
Highly Cited
2004
Galectin-3 Precipitates as a Pentamer with Synthetic Multivalent Carbohydrates and Forms Heterogeneous Cross-linked Complexes*
Galectin-3 is unique among the galectin family of animal lectins in its biological activities and structure. Most members of the… Expand
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Highly Cited
2003
Highly Cited
2003
Critical role of galectin-3 in phagocytosis by macrophages.
Galectin-3 is a member of a large family of animal lectins. This protein is expressed abundantly by macrophages, but its function… Expand
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Highly Cited
2000
Highly Cited
2000
Galectin-3 induces endothelial cell morphogenesis and angiogenesis.
Increasing evidence suggests that carbohydrate-binding proteins play an essential role in tumor growth and metastasis. However… Expand
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Highly Cited
1996
Highly Cited
1996
Expression of galectin-3 modulates T-cell growth and apoptosis.
Galectin-3 is a member (if a large family of beta-galactoside-binding animal lectins. It has been shown that the expression of… Expand
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