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Implications of endogenous tumor cell surface lectins as mediators of cellular interactions and lung colonization.
A monoclonal antibody (mAb) designated 5D7 that is directed against endogenous, galactoside-specific lectin and binds to the surface of various tumor cells was used to examine the involvement of cellExpand
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Transformation‐related changes in the expression of endogenous cell lectins
Endogenous lectins purified from UV‐2237‐IP3 murine fibrosarcoma cells by affinity chromatography consisted of two polypeptide species of Mr 14,500 (L‐14.5) and Mr 34,000 (L‐34). Antibodies againstExpand
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Quantitation of cytokine-stimulated migration of endothelium and epithelium by a new assay using microcarrier beads.
Recent studies have identified a group of cytokines which appear to be cell-specific regulators of mobility in nonleukocytic mammalian cells. One example is scatter factor (SF), a soluble protein(s)Expand
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Purified Scatter Factor Stimulates Epithelial and Vascular Endothelial Cell Migration
Abstract Fibroblasts and smooth muscle cells release a protein activity which causes epithelial sheets to “scatter” into isolated cells. Purification of scatter factor (SF) activity fromExpand
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Smooth muscle-derived factor stimulates mobility of human tumor cells.
Invasion of normal tissues is a complex process which requires active locomotion of malignant cells. Recent studies have identified a group of proteins which appear to be specific regulators of cellExpand
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Differential expression of endogenous lectins on the surface of nontumorigenic, tumorigenic, and metastatic cells.
A monoclonal antibody that was found to recognize endogenous galactoside-specific lectins of various tumor cells by immunoblot analysis was used for quantitative analyses of cell surface lectin onExpand
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Selective labeling of functional groups on membrane proteins or glycoproteins using reactive biotin derivatives and 125I-streptavidin.
Amino groups, sulfhydryl groups or oxidation-induced aldehydes on erythrocyte membrane proteins and/or glycoproteins, were reacted with biotinyl N-hydroxysuccinimide ester (BNHS),Expand
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Studies on the mechanism of scatter factor. Effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly.
Scatter factor (SF) is a cytokine that causes cohesive epithelial colonies to 'scatter' into isolated cells and stimulates epithelial cell migration. To investigate SF's mechanism(s), we screenedExpand
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Human placenta contains an epithelial scatter protein.
Scatter factor (SF) is a protein produced by cultured fibroblasts which causes epithelia to "scatter" into isolated cells. We found significant scatter activity in vivo in second trimester (but notExpand
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Monoclonal antibodies to endogenous galactose‐specific tumor cell lectins.
A monoclonal antibody, 5D7, was obtained after immunization of syngeneic mice with B16 melanoma cell extracts enriched for endogenous lectin activity and screening for inhibition of lectin‐mediatedExpand
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