Galectin-3 induces endothelial cell morphogenesis and angiogenesis.
Galectins: A family of animal β-galactoside-binding lectins
Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin.
- P. Nangia-Makker, V. Hogan, A. Raz
- Biology, MedicineJournal of the National Cancer Institute
- 18 December 2002
Tumor growth, angiogenesis, and spontaneous metastasis in vivo were statistically significantly reduced in mice fed MCP, presumably via its effects on galectin-3 function, and the importance of dietary carbohydrate compounds as agents for the prevention and/or treatment of cancer is stressed.
CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis.
It is reported that secreted extracellular Gal-3 can signal apoptosis of human T leukemia cell lines, human peripheral blood mononuclear cells, and activated mouse T cells after binding to cell surface glycoconjugate receptors through carbohydrate-dependent interactions because the apoptotic effect was found to be inhibited by lactose, specific sugar inhibitor, and to be dose dependent.
Murine models to evaluate novel and conventional therapeutic strategies for cancer.
- J. Talmadge, Rakesh K. Singh, I. Fidler, A. Raz
- Biology, MedicineAmerican Journal of Pathology
- 1 March 2007
It is recommended that future studies incorporate orthotopic and spontaneous metastasis models (syngeneic and xenogenic) because they incorporate microenvironmental interactions, in addition to confirmatory autochthonous models and/or genetically engineered models, for molecular therapeutics.
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9.
It is reported that the amino-terminal domain of galectin-3 contains a cleavage site for two members of the matrix metalloproteinase family of enzymes: the 72 kDa (gelatinase A, MMP-2) and the 92 kDa (-) proteinases.
Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family.
It is demonstrated that expression of galectin-3 in human breast carcinoma BT549 cells inhibits cis-diamminedichloroplatinum (cisplatin)-induced poly(ADP-ribose) polymerase degradation and apoptosis, without altering B cl-2, Bcl-X(L), or Bax expressions.
Galectin-3 and metastasis
Recently, it has been shown that galectin-3 can be a reliable diagnostic marker in certain cancers and one of the target proteins of cancer treatment.
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
It is demonstrated here that p53 can cooperate with the activated Ha-ras oncogene to transform normal embryonic cells, and the resultant foci contain cells of a markedly altered morphology which produce high levels of p53.
Galectin-3, a Novel Binding Partner of β-Catenin
- T. Shimura, Y. Takenaka, Souichi Tsutsumi, V. Hogan, A. Kikuchi, A. Raz
- BiologyCancer Research
- 15 September 2004
The β-catenin–gal-3–binding sequences, which are in the NH2 and COOH termini of the proteins encompassing amino acid residues 1 to 131 and 143 to 250, respectively, indicate that gal-3 is a novel binding partner for β-Catenin involved in the regulation of Wnt/β- catenin signaling pathway.