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Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin.
- P. Nangia-Makker, V. Hogan, +4 authors A. Raz
- Medicine, Biology
- Journal of the National Cancer Institute
- 18 December 2002
BACKGROUND The role of dietary components in cancer progression and metastasis is an emerging field of clinical importance. Many stages of cancer progression involve carbohydrate-mediated recognition… Expand
CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis.
Galectin (Gal)-3, a M(r) 31000 member of the beta-galactoside-binding protein family, is a multifunctional protein implicated in a variety of biological functions, including tumor cell adhesion,… Expand
Murine models to evaluate novel and conventional therapeutic strategies for cancer.
Animal models, by definition, are an approximation of reality, and their use in developing anti-cancer drugs is controversial. Positive retrospective clinical correlations have been identified with… Expand
Galectin-3 and metastasis
Galectin-3, a 31 kDa member of the β-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and… Expand
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
The cellular tumour antigen p53 is found at elevated levels in a wide variety of transformed cells (for reviews see refs 1, 2). Very little is yet known about the precise relationship of p53 to… Expand
Galectin-3, a Novel Binding Partner of β-Catenin
- Tatsuo Shimura, Y. Takenaka, Souichi Tsutsumi, V. Hogan, A. Kikuchi, A. Raz
- Cancer Research
- 15 September 2004
Galectin-3 (gal-3), a pleiotrophic protein, is an important regulator of tumor metastasis, which like β-catenin shuttles between the nucleus and the cytosol in a phosphorylation-dependent manner. We… Expand
The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein 1
Autocrine motility factor receptor (AMFR) is a cell surface glycoprotein of molecular weight 78 000 (gp78), mediating cell motility signaling in vitro and metastasis in vivo. Here, we cloned the… Expand
Overexpression of the autocrine motility factor/phosphoglucose isomerase induces transformation and survival of NIH-3T3 fibroblasts.
Autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) is a ubiquitous cytosolic enzyme and is produced as a leaderless secretory protein, released from cells via a nonclassical pathway.… Expand
Galectin-3 Translocates to the Perinuclear Membranes and Inhibits Cytochrome c Release from the Mitochondria
Galectin-3 is a multifunctional oncogenic protein found in the nucleus and cytoplasm and also the extracellular milieu. Although recent studies demonstrated an anti-apoptotic activity of galectin-3,… Expand
Nuclear Export of Phosphorylated Galectin-3 Regulates Its Antiapoptotic Activity in Response to Chemotherapeutic Drugs
- Y. Takenaka, T. Fukumori, +5 authors A. Raz
- Biology, Medicine
- Molecular and Cellular Biology
- 15 May 2004
ABSTRACT Galectin-3 (Gal-3), a member of the β-galactoside binding protein family containing the NWGR antideath motif of the Bcl-2 protein family, is involved in various aspects of cancer… Expand