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GZMB protein, human

Known as: Granzyme 2, C11, SECT 
Granzyme B (247 aa, ~28 kDa) is encoded by the human GZMB gene. This protein plays a role in the mediation of cell-dependent cytotoxicity.
National Institutes of Health

Related topics

Related topics

14 relations
Caspase Cascade PathwayCell-Mediated CytolysisCytotoxic T-LymphocytesEnzyme Gene

Broader (2)

Granzymesgranzyme B

Papers overview

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Highly Cited
2019
Highly Cited
2019
Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells
ABSTRACT Extracellular vesicles (EVs) are secreted membrane vesicles, which play complex physiological and pathological functions… 
Highly Cited
2014
Highly Cited
2014
Autophagic degradation of GZMB/granzyme B
The crucial issue for defining successful natural killer (NK)-based anticancer therapy is the ability of tumor cells to activate… 
Highly Cited
2006
Highly Cited
2006
The Cytotoxic Lymphocyte Protease, Granzyme B, Targets the Cytoskeleton and Perturbs Microtubule Polymerization Dynamics*
Granzyme B, a serine protease derived from cytotoxic T lymphocyte (CTL) and Natural Killer (NK) cell granules, plays an important… 
Highly Cited
2000
Highly Cited
2000
Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis*
We used yeast two-hybrid screening to identify the cytoskeletal protein filamin as a ligand for the proapoptotic protease… 
Highly Cited
1996
Highly Cited
1996
Nuclear Transport of Granzyme B (Fragmentin-2)
Cytotoxic T and natural killer cells are able to kill their target cells through synergistic action of the pore-forming protein… 
Highly Cited
1995
Highly Cited
1995
B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors.
B7-CD28 costimulation is essential for the activation of CD4+ T helper cells, mainly by regulating IL-2 and other cytokine… 
Highly Cited
1992
Highly Cited
1992
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
We recently reported the purification of a lymphocyte granule protein called "fragmentin," which was identified as a serine… 
Highly Cited
1992
Highly Cited
1992
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
We report the purification from a rat natural killer (RNK) large granular lymphocyte leukemia of a 32-kD granule protein that… 
Highly Cited
1991
Highly Cited
1991
The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.
To kill other cells, lymphocytes can exocytose granules that contain serine proteases and pore-forming proteins (perforins). We… 
Highly Cited
1988
Highly Cited
1988
Characterization of three serine esterases isolated from human IL-2 activated killer cells.
Human peripheral blood mononuclear cells, activated for 14 to 20 days with 1000 U/ml rIL-2, develop strong cytotoxicity for NK… 
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