Skip to search formSkip to main contentSkip to account menu

GW406381X

Known as: GW406381 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PyrazolesPyridazines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Biomarker exposure–response relationships as the basis for rational dose selection: Lessons from a simulation exercise using a selective COX‐2 inhibitor
An exposure–response model was used to characterize the pharmacokinetic‐pharmacodynamic relationship of GW406381, a COX‐2… 
2009
2009
A randomized, double-blind, placebo-controlled trial of a selective COX-2 inhibitor, GW406381, in patients with postherpetic neuralgia.
2009
2009
A Randomized, Controlled, Dose-ranging Study Investigating Single Doses of GW406381, Naproxen Sodium, or Placebo in Patients With Acute Pain After Third Molar Tooth Extraction
ObjectivesTo evaluate the efficacy and tolerability of 4 doses of GW406381, a cyclooxygenase-2 inhibitor, compared with placebo… 
2008
2008
Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies.
CONTEXT GW406381 is an investigational, highly selective cyclooxygenase-2 (COX-2) inhibitor that is effective in animal models of… 
2008
2008
A double‐blind, randomized, placebo‐controlled, single‐dose study of the cyclooxygenase‐2 inhibitor, GW406381, as a treatment for acute migraine
The objective of the present study was to explore the clinical efficacy and tolerability of GW406381, a cyclooxygenase‐2 (COX‐2… 
2007
2007
GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury
Highly Cited
2005
Highly Cited
2005
The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization
The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively present in the spinal cord and has been… 
2004
2004
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)