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NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study
TLDR
One 60-min application of NGX-4010 provided rapid and sustained pain relief in patients with postherpetic neuralgia and no adverse events were associated with treatment except for local reactions at the site of application and those related to treatment-associated pain. Expand
A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain.
TLDR
Slow titration of ziconotide, a nonopioid analgesic, to a low maximum dose resulted in significant improvement in pain and was better tolerated than in two previous controlled trials that used a faster titration to a higher mean dose. Expand
Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival.
TLDR
IDDSs improved clinical success in pain control, reduced pain, significantly relieved common drug toxicities, and improved survival in patients with refractory cancer pain. Expand
Polyanalgesic Consensus Conference 2012: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel
Introduction:  The use of intrathecal (IT) infusion of analgesic medications to treat patients with chronic refractory pain has increased since its inception in the 1980s, and the need for clinicalExpand
Polyanalgesic Consensus Conference 2007: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel
TLDR
An expert panel of physicians convened in 2007 to update previous recommendations and to form guidelines for the rational use of intrathecal opioid and nonopioid agents. Expand
Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients.
TLDR
Oral transmucosal fentanyl citrate (OTFC), a unique formulation of the opioid fentanyl, has been shown to provide meaningful pain relief within 5 minutes in patients following surgery and appears effective in the treatment of cancer-related breakthrough pain. Expand
Best Practices for Intrathecal Drug Delivery for Pain
The objective of this study was to identify best practices and provide guidance to clinicians to ensure safety and optimize intrathecal drug delivery for chronic intractable pain.
An Updated Interdisciplinary Clinical Pathway for CRPS: Report of an Expert Panel
TLDR
The current pathophysiology as it is known is reviewed, the purported treatments are reviewed, and a modified clinical pathway (guideline) is provided that attempts to expand the scope of previous guidelines. Expand
Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel.
TLDR
A Polyanalgesic Consensus Conference 2003 was organized to review the literature on intraspinal drug infusion and develop guidelines for optimizing drug dosage and concentration and to clarify issues pertaining to compounding of drugs. Expand
Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain
TLDR
Overall, sublingual fentanyl ODT was well-tolerated both systemically and sublingually, with 41 patients experiencing ≥1 study drug-related adverse event (AE) and long-term tolerability was well tolerated over 12 months of treatment. Expand
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