FAQ

GRN protein, human

Known as: granulin protein, human, proepithelin protein, human, PC-cell-derived growth factor, human 
Granulins (593 aa, ~64 kDa) is encoded by the human GRN gene. This protein is involved in receptor-mediated signaling.

Topic mentions per year

Topic mentions per year

1975-2017
02419752017

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7 relations
Extracellular SpaceGRN geneGRN wt AlleleGrowth Factor
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Broader (1)

granulin

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
GRN protein, human
Growth Factor
Signal Transduction
Extracellular Space
GRN gene
GRN wt Allele

Papers overview

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2010
2010
HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins.
AIM HDL has anti-inflammatory effects on macrophages, although the mechanism of action remains unclear. We hypothesized that HDL… (More)
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2009
2009
Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.
The growth factor proepithelin has recently emerged as an important regulator of transformation in several physiological and… (More)
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Highly Cited
2006
Highly Cited
2006
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.
The growth factor proepithelin (also known as progranulin, acrogranin, PC-derived growth factor, or granulin-epithelin precursor… (More)
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2006
2006
A novel hematopoietic granulin induces proliferation of goldfish (Carassius auratus L.) macrophages.
Granulins are a group of highly conserved growth factors that have been described from a variety of organisms spanning the… (More)
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Highly Cited
2002
Highly Cited
2002
Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair
Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound… (More)
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Highly Cited
2000
Highly Cited
2000
Cellular localization of gene expression for progranulin.
Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin… (More)
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1998
1998
The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study
Ascorbic acid is a required cofactor in the hydroxylations of lysine and proline necessary for collagen formation; its role in… (More)
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1997
1997
Isolation and N-terminal sequence of multiple forms of granulins in human urine.
Three molecular forms of granulins (also known as epithelins) were isolated, for the first time, in human urine. Their N-terminal… (More)
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1993
1993
Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio).
Granulins are cysteine-rich polypeptides purified from human and rat hematopoietic cells and structurally related to the… (More)
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Highly Cited
1990
Highly Cited
1990
Granulins, a novel class of peptide from leukocytes.
We report the isolation and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which… (More)
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