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GRN protein, human

Known as: granulin protein, human, proepithelin protein, human, PC-cell-derived growth factor, human 
Granulins (593 aa, ~64 kDa) is encoded by the human GRN gene. This protein is involved in receptor-mediated signaling.
National Institutes of Health

Papers overview

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2017
2017
Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN), cause neuronal ceroid lipofuscinosis (NCL) or… Expand
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Review
2012
Review
2012
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is… Expand
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2009
2009
The growth factor proepithelin functions as an important regulator of proliferation and motility. Proepithelin is overexpressed… Expand
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Review
2007
Review
2007
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries… Expand
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2003
2003
AIMS To study the influence of peptides and proteolytic enzymes in the osmotic adaptation of Lactobacillus casei. METHODS AND… Expand
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Highly Cited
2002
Highly Cited
2002
Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound… Expand
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Highly Cited
2000
Highly Cited
2000
Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin… Expand
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Review
1998
Review
1998
The granulin/epithelin motif defines a family of structurally unique proteins, of great evolutionary antiquity, which have been… Expand
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1992
1992
Granulins are a family of cysteine rich polypeptides some of which have growth modulatory activity. We showed previously that the… Expand
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Highly Cited
1992
Highly Cited
1992
Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin… Expand
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