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GRN protein, human
Known as:
granulin protein, human
, proepithelin protein, human
, PC-cell-derived growth factor, human
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Granulins (593 aa, ~64 kDa) is encoded by the human GRN gene. This protein is involved in receptor-mediated signaling.
National Institutes of Health
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Related topics
Related topics
8 relations
Extracellular Space
GRN gene
GRN wt Allele
Growth Factor
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Broader (1)
granulin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations
Christopher J. Holler
,
Georgia Taylor
,
Qiudong Deng
,
T. Kukar
eNeuro
2017
Corpus ID: 3716361
Visual Abstract Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN), cause neuronal ceroid…
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Review
2012
Review
2012
Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration*
B. Cenik
,
C. Sephton
,
Bercin Kutluk Cenik
,
J. Herz
,
Gang Yu
The Journal of Biological Chemistry
2012
Corpus ID: 39862949
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is…
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Review
2007
Review
2007
Progranulin in frontotemporal lobar degeneration and neuroinflammation
Z. Ahmed
,
I. Mackenzie
,
M. Hutton
,
D. Dickson
Journal of Neuroinflammation
2007
Corpus ID: 10752933
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries…
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Highly Cited
2003
Highly Cited
2003
Adaptation to high salt in Lactobacillus: role of peptides and proteolytic enzymes
M. Piuri
,
C. Sánchez-Rivas
,
S. Ruzal
Journal of applied microbiology
2003
Corpus ID: 33706701
Aims: To study the influence of peptides and proteolytic enzymes in the osmotic adaptation of Lactobacillus casei.
Highly Cited
2002
Highly Cited
2002
Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair
Jing Zhu
,
C. Nathan
,
+8 authors
A. Ding
Cell
2002
Corpus ID: 15414947
Highly Cited
2000
Highly Cited
2000
Cellular Localization of Gene Expression for Progranulin
R. Daniel
,
Z. He
,
K. Carmichael
,
J. Halper
,
A. Bateman
The journal of histochemistry and cytochemistry…
2000
Corpus ID: 9050076
Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin…
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Review
1998
Review
1998
Granulins: the structure and function of an emerging family of growth factors.
A. Bateman
,
H. Bennett
The Journal of endocrinology
1998
Corpus ID: 1019650
The granulin/epithelin motif defines a family of structurally unique proteins, of great evolutionary antiquity, which have been…
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Highly Cited
1992
Highly Cited
1992
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
V. Bhandari
,
R. Palfree
,
A. Bateman
Proceedings of the National Academy of Sciences…
1992
Corpus ID: 37606641
Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin…
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Highly Cited
1992
Highly Cited
1992
Structure and chromosomal location of the human granulin gene.
V. Bhandari
,
A. Bateman
Biochemical and biophysical research…
1992
Corpus ID: 28887320
Highly Cited
1990
Highly Cited
1990
Granulins, a novel class of peptide from leukocytes.
A. Bateman
,
D. Belcourt
,
H. Bennett
,
C. Lazure
,
S. Solomon
Biochemical and biophysical research…
1990
Corpus ID: 34782075
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