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GRN protein, human

Known as: granulin protein, human, proepithelin protein, human, PC-cell-derived growth factor, human 
Granulins (593 aa, ~64 kDa) is encoded by the human GRN gene. This protein is involved in receptor-mediated signaling.
National Institutes of Health

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Related topics

8 relations
Extracellular SpaceGRN geneGRN wt AlleleGrowth Factor
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Broader (1)

granulin

Papers overview

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Highly Cited
2017
Highly Cited
2017
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations
Visual Abstract Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN), cause neuronal ceroid… 
Review
2012
Review
2012
Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration*
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is… 
Review
2007
Review
2007
Progranulin in frontotemporal lobar degeneration and neuroinflammation
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries… 
Highly Cited
2003
Highly Cited
2003
Adaptation to high salt in Lactobacillus: role of peptides and proteolytic enzymes
Aims: To study the influence of peptides and proteolytic enzymes in the osmotic adaptation of Lactobacillus casei. 
Highly Cited
2002
Highly Cited
2002
Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair
Highly Cited
2000
Highly Cited
2000
Cellular Localization of Gene Expression for Progranulin
Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin… 
Review
1998
Review
1998
Granulins: the structure and function of an emerging family of growth factors.
The granulin/epithelin motif defines a family of structurally unique proteins, of great evolutionary antiquity, which have been… 
Highly Cited
1992
Highly Cited
1992
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin… 
Highly Cited
1992
Highly Cited
1992
Structure and chromosomal location of the human granulin gene.
Highly Cited
1990
Highly Cited
1990
Granulins, a novel class of peptide from leukocytes.
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