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GRN protein, human

Known as: granulin protein, human, proepithelin protein, human, PC-cell-derived growth factor, human 
Granulins (593 aa, ~64 kDa) is encoded by the human GRN gene. This protein is involved in receptor-mediated signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Extracellular SpaceGRN geneGRN wt AlleleGrowth Factor

Broader (1)

granulin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations
Visual Abstract Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN), cause neuronal ceroid… 
2013
2013
Progranulin does not inhibit TNF and lymphotoxin‐α signalling through TNF receptor 1
Progranulin (proepithelin, granulin precursor) has been recently suggested to exhibit anti‐inflammatory properties by directly… 
Highly Cited
2009
Highly Cited
2009
Synthesis and optical properties of novel organic–inorganic hybrid nanolayer structure semiconductors
Highly Cited
2006
Highly Cited
2006
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.
The growth factor proepithelin (also known as progranulin, acrogranin, PC-derived growth factor, or granulin-epithelin precursor… 
Highly Cited
2003
Highly Cited
2003
Adaptation to high salt in Lactobacillus: role of peptides and proteolytic enzymes
Aims: To study the influence of peptides and proteolytic enzymes in the osmotic adaptation of Lactobacillus casei. 
Highly Cited
1998
Highly Cited
1998
Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor).
The PC cell line is a highly tumorigenic, insulin-independent, teratoma-derived cell line isolated from the nontumorigenic… 
Highly Cited
1994
Highly Cited
1994
Producer immunity towards the lantibiotic Pep5: identification of the immunity gene pepI and localization and functional analysis of its gene product
The lantibiotic Pep5 is produced by Staphylococcus epidermidis 5. Pep5 production and producer immunity are associated with the… 
Highly Cited
1992
Highly Cited
1992
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin… 
Highly Cited
1992
Highly Cited
1992
Structure and chromosomal location of the human granulin gene.
Highly Cited
1990
Highly Cited
1990
Granulins, a novel class of peptide from leukocytes.
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