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GRN protein, human

Known as: granulin protein, human, proepithelin protein, human, PC-cell-derived growth factor, human 
Granulins (593 aa, ~64 kDa) is encoded by the human GRN gene. This protein is involved in receptor-mediated signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Extracellular SpaceGRN geneGRN wt AlleleGrowth Factor
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Broader (1)

granulin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration*
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is… Expand
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Highly Cited
2009
Highly Cited
2009
Synthesis and optical properties of novel organic–inorganic hybrid nanolayer structure semiconductors
Abstract We report on the synthesis of some novel organic–inorganic hybrid 2D perovskite semiconductors (R-(CH2)nNH3)2PbX4. These… Expand
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Review
2007
Review
2007
Progranulin in frontotemporal lobar degeneration and neuroinflammation
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries… Expand
Highly Cited
2006
Highly Cited
2006
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.
The growth factor proepithelin (also known as progranulin, acrogranin, PC-derived growth factor, or granulin-epithelin precursor… Expand
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Highly Cited
2002
Highly Cited
2002
Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair
Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound… Expand
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Highly Cited
2000
Highly Cited
2000
Cellular Localization of Gene Expression for Progranulin
Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin… Expand
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Review
1998
Review
1998
Granulins: the structure and function of an emerging family of growth factors.
The granulin/epithelin motif defines a family of structurally unique proteins, of great evolutionary antiquity, which have been… Expand
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Highly Cited
1992
Highly Cited
1992
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin… Expand
Highly Cited
1992
Highly Cited
1992
Structure and chromosomal location of the human granulin gene.
Granulins are a family of cysteine rich polypeptides some of which have growth modulatory activity. We showed previously that the… Expand
Highly Cited
1990
Highly Cited
1990
Granulins, a novel class of peptide from leukocytes.
We report the isolation and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which… Expand
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