GRN protein, human

Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN), cause neuronal ceroid lipofuscinosis (NCL) or… Expand

GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is… Expand

The growth factor proepithelin functions as an important regulator of proliferation and motility. Proepithelin is overexpressed… Expand

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries… Expand

AIMS To study the influence of peptides and proteolytic enzymes in the osmotic adaptation of Lactobacillus casei. METHODS AND… Expand

Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound… Expand

Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin… Expand

The granulin/epithelin motif defines a family of structurally unique proteins, of great evolutionary antiquity, which have been… Expand

Granulins are a family of cysteine rich polypeptides some of which have growth modulatory activity. We showed previously that the… Expand

Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin… Expand