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GRN wt Allele

Known as: CLN11, PGRN, GP88 
Human GRN wild-type allele is located in the vicinity of 17q21.32 and is approximately 8 kb in length. This allele, which encodes granulins protein… 
National Institutes of Health

Related topics

Related topics

5 relations
17q21.32GRN protein, humanSignal TransductionWound Repair Pathway

Broader (1)

GRN gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Neuroprotective effects of progranulin in ischemic mice
2012
2012
The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1.
Progranulin (PGRN), a secreted growth factor, regulates the proliferation of various epithelial cells. Its mechanism of action is… 
Highly Cited
2010
Highly Cited
2010
Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures
2009
2009
Genetic testing in familial AD and FTD: Mutation and phenotype spectrum in a Danish cohort
Autosomal dominantly transmitted Alzheimer's disease (AD) and frontotemporal dementia (FTD) are genetically heterogeneous… 
Review
2006
Review
2006
Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Two genetically distinct types of frontotemporal dementia (FTD) are linked to chromosome 17q21. FTD with parkinsonism (FTDP-17… 
2006
2006
PC Cell–Derived Growth Factor Stimulates Proliferation and Confers Trastuzumab Resistance to Her-2-Overexpressing Breast Cancer Cells
Purpose: Trastuzumab is only effective in 25% to 30% of the administered breast cancer patients who overexpress the erbB2/Her-2… 
Highly Cited
2004
Highly Cited
2004
PC Cell-Derived Growth Factor Mediates Tamoxifen Resistance and Promotes Tumor Growth of Human Breast Cancer Cells
PC cell-derived growth factor, also known as progranulin, is an Mr 88,000 growth factor (referred as PCDGF/GP88) overexpressed in… 
Highly Cited
2002
Highly Cited
2002
Gemcitabine, epirubicin and paclitaxel: pharmacokinetic and pharmacodynamic interactions in advanced breast cancer.
BACKGROUND The objectives of this study were to investigate the disposition of gemcitabine, epirubicin, paclitaxel, 2',2… 
Highly Cited
1999
Highly Cited
1999
Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells.
PC cell-derived growth factor (PCDGF) is an 88 kDa glycosylated protein isolated from a highly tumorigenic mouse teratoma derived… 
Highly Cited
1998
Highly Cited
1998
Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor).
The PC cell line is a highly tumorigenic, insulin-independent, teratoma-derived cell line isolated from the nontumorigenic… 
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