GRN wt Allele

Known as: CLN11, PGRN, GP88 
Human GRN wild-type allele is located in the vicinity of 17q21.32 and is approximately 8 kb in length. This allele, which encodes granulins protein… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In humans, PGRN haploinsufficiency is a… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Mutations that lead to a loss of progranulin (PGRN) explain a considerable portion of the occurrence of frontotemporal… (More)
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Review
2008
Review
2008
Frontotemporal lobar degeneration (FTLD) represents a collection of neurodegenerative diseases of frontal and temporal brain… (More)
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Highly Cited
2008
Highly Cited
2008
Two hundred and twenty-three consecutive patients fulfilling clinical diagnostic criteria for frontotemporal lobar degeneration… (More)
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Review
2007
Review
2007
Mutations in the progranulin gene (PGRN), on chromosome 17q21, have recently been identified as a major cause of familial… (More)
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Highly Cited
2006
Highly Cited
2006
Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions (both cytoplasmic and nuclear) of unknown nature… (More)
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Highly Cited
2004
Highly Cited
2004
Metastasis is a multi-step process involved in the progression of breast cancer to a disease with poor prognosis. Growth factor… (More)
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Highly Cited
2001
Highly Cited
2001
PC-cell-derived growth factor (PCDGF) is an 88-kDa glycoprotein corresponding to the granulin precursor. We have reported that… (More)
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Highly Cited
2000
Highly Cited
2000
The stimuli controlling pharyngeal dilator muscles are poorly defined. Local mechanoreceptors are a leading possibility. To… (More)
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Highly Cited
2000
Highly Cited
2000
PC-cell derived growth factor (PCDGF) is an 88-kDa growth factor originally purified from the highly tumorigenic teratoma PC cell… (More)
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