Skip to search formSkip to main contentSkip to account menu

GRN gene

Known as: PROGRANULIN, Granulin Gene, GRN 
This gene is involved in cytokine-like activity.
National Institutes of Health

Related topics

Related topics

4 relations
GRN protein, humanSignal Transductiongranulin

Narrower (1)

GRN wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Molecular Pathogenesis of Genetic and Inherited Diseases Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity
Mutations resulting in progranulin haploinsufficiency cause disease in patients with a subset of frontotemporal lobar… 
Review
2006
Review
2006
Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease classically defined by the impairment of the voluntary motor… 
Review
2006
Review
2006
Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Two genetically distinct types of frontotemporal dementia (FTD) are linked to chromosome 17q21. FTD with parkinsonism (FTDP-17… 
Highly Cited
2004
Highly Cited
2004
PC Cell-Derived Growth Factor Mediates Tamoxifen Resistance and Promotes Tumor Growth of Human Breast Cancer Cells
PC cell-derived growth factor, also known as progranulin, is an Mr 88,000 growth factor (referred as PCDGF/GP88) overexpressed in… 
Review
2003
Review
2003
Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis.
Highly Cited
2002
Highly Cited
2002
The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system.
Levels of dlk, an EGF-like homeotic protein, are critical for several differentiation processes. Because growth and… 
Highly Cited
1998
Highly Cited
1998
The Granulin/Epithelin Precursor Abrogates the Requirement for the Insulin-like Growth Factor 1 Receptor for Growth in Vitro *
3T3 cells null for the type 1 insulin-like growth factor receptor are refractory to stimulation by a variety of purified growth… 
Highly Cited
1998
Highly Cited
1998
Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor).
The PC cell line is a highly tumorigenic, insulin-independent, teratoma-derived cell line isolated from the nontumorigenic… 
Highly Cited
1994
Highly Cited
1994
Producer immunity towards the lantibiotic Pep5: identification of the immunity gene pepI and localization and functional analysis of its gene product
The lantibiotic Pep5 is produced by Staphylococcus epidermidis 5. Pep5 production and producer immunity are associated with the… 
Highly Cited
1992
Highly Cited
1992
Structure and chromosomal location of the human granulin gene.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)