FAQ

GRN gene

Known as: PROGRANULIN, Granulin Gene, GRN 
This gene is involved in cytokine-like activity.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1948-2017
010020019482016

Related topics

Related topics

4 relations
GRN protein, humanSignal Transductiongranulin

Narrower (1)

GRN wt Allele

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
GRN gene
Signal Transduction
GRN wt Allele
granulin
GRN protein, human

Papers overview

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Highly Cited
2011
Highly Cited
2011
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as… (More)
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Highly Cited
2011
Highly Cited
2011
Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes*♦
TAR DNA-binding protein 43 (TDP-43) is associated with a spectrum of neurodegenerative diseases. Although TDP-43 resembles… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies
Phosphorylated and proteolytically cleaved TDP-43 is a major component of the ubiquitin-positive inclusions in the most common… (More)
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Highly Cited
2007
Highly Cited
2007
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
TAR DNA binding protein-43 (TDP-43) is the pathologic substrate of neuronal and glial inclusions in frontotemporal lobar… (More)
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Highly Cited
2007
Highly Cited
2007
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.
Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We… (More)
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Highly Cited
2006
Highly Cited
2006
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. A large proportion… (More)
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Highly Cited
2006
Highly Cited
2006
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions (both cytoplasmic and nuclear) of unknown nature… (More)
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Highly Cited
2004
Highly Cited
2004
WINPEPI (PEPI-for-Windows): computer programs for epidemiologists
BACKGROUND: The WINPEPI (PEPI-for-Windows) computer programs for epidemiologists are designed for use in practice and research in… (More)
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Highly Cited
2003
Highly Cited
2003
Progranulin is a mediator of the wound response
Annually, 1.25 million individuals suffer burns in the United States and 6.5 million experience chronic skin ulcers, often from… (More)
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Highly Cited
2003
Highly Cited
2003
Developmental gene regulatory network architecture across 500 million years of echinoderm evolution.
Evolutionary change in morphological features must depend on architectural reorganization of developmental gene regulatory… (More)
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