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GRN gene

Known as: PROGRANULIN, Granulin Gene, GRN 
This gene is involved in cytokine-like activity.
National Institutes of Health

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Related topics

4 relations
GRN protein, humanSignal Transductiongranulin

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GRN wt Allele

Papers overview

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Highly Cited
2007
Highly Cited
2007
Prosurvival function of the granulin‐epithelin precursor is important in tumor progression and chemoresponse
The granulin‐epithelin precursor (GEP/PCDGF), a 68–88 kDa secreted glycoprotein, has been shown to be an important growth and… 
Review
2006
Review
2006
Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease classically defined by the impairment of the voluntary motor… 
Highly Cited
2004
Highly Cited
2004
PC Cell-Derived Growth Factor Mediates Tamoxifen Resistance and Promotes Tumor Growth of Human Breast Cancer Cells
PC cell-derived growth factor, also known as progranulin, is an Mr 88,000 growth factor (referred as PCDGF/GP88) overexpressed in… 
Highly Cited
2002
Highly Cited
2002
The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system.
Levels of dlk, an EGF-like homeotic protein, are critical for several differentiation processes. Because growth and… 
2000
2000
Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats
Highly Cited
1998
Highly Cited
1998
Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor).
The PC cell line is a highly tumorigenic, insulin-independent, teratoma-derived cell line isolated from the nontumorigenic… 
Highly Cited
1994
Highly Cited
1994
Producer immunity towards the lantibiotic Pep5: identification of the immunity gene pepI and localization and functional analysis of its gene product
The lantibiotic Pep5 is produced by Staphylococcus epidermidis 5. Pep5 production and producer immunity are associated with the… 
1993
1993
Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio).
Highly Cited
1977
Highly Cited
1977
Biophysical properties of the structural components of a granulosis virus isolated from the cabbage white butterfly (Pieris brassicae).
Highly Cited
1975
Highly Cited
1975
Comparative studies of baculovirus granulins and polyhedrins.
Granulins and polyhedrins from five baculoviruses exhibit similar chemical and physical properties. Although similarities are… 
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