GRIN2B wt Allele

Known as: MGC142180, NMDAR2B, hNR3 
Human GRIN2B wild-type allele is located in the vicinity of 12p12 and is approximately 419 kb in length. This allele, which encodes glutamate… (More)
National Institutes of Health

Related topics

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10 relations
12p12Alzheimer's Disease Pathway KEGGERBB4 Signaling PathwayHomo sapiens
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Papers overview

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Highly Cited
2007
Highly Cited
2007
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.
Well-documented experimental evidence from both in vitro and in vivo models of stroke strongly supports the critical involvement… (More)
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Highly Cited
2006
Highly Cited
2006
Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons.
Early in development, neurons only express NR1/NR2B-containing N-methyl-d-aspartate (NMDA) receptors. Later, NR2A subunits are… (More)
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Highly Cited
2005
Highly Cited
2005
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.
NR2A and NR2B are the predominant NR2 NMDA receptor subunits expressed in cortex and hippocampus. The relative expression level… (More)
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Highly Cited
2005
Highly Cited
2005
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.
NMDA receptor (NMDAR) 2A (NR2A)- and NR2B-type NMDARs coexist in synapses of CA1 pyramidal cells. Recent studies using… (More)
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Highly Cited
2003
Highly Cited
2003
The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1
The NMDA subtype of glutamate receptors (NMDAR) at excitatory neuronal synapses plays a key role in synaptic plasticity. The… (More)
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Highly Cited
2002
Highly Cited
2002
Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease
Previous work suggests N-methyl-D-aspartate receptor (NMDAR) activation may be involved in degeneration of medium-sized spiny… (More)
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Review
2001
Review
2001
NMDA receptor subunits: diversity, development and disease
N-methyl-D-aspartate receptors (NMDARs) are present at many excitatory glutamate synapses in the central nervous system and… (More)
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Highly Cited
2000
Highly Cited
2000
A developmental change in NMDA receptor-associated proteins at hippocampal synapses.
The membrane-associated guanylate kinases [Chapsyn-110/postsynaptic density-93 (PSD-93), synapse-associated protein-90 (SAP-90… (More)
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Highly Cited
1998
Highly Cited
1998
Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor.
Activation and Thr286 autophosphorylation of calcium/calmodulindependent kinase II (CaMKII) following Ca2+ influx via N-methyl-D… (More)
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Highly Cited
1992
Highly Cited
1992
Heteromeric NMDA receptors: molecular and functional distinction of subtypes.
The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique… (More)
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