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GRIN2B wt Allele

Known as: MGC142180, NMDAR2B, hNR3 
Human GRIN2B wild-type allele is located in the vicinity of 12p12 and is approximately 419 kb in length. This allele, which encodes glutamate… 
National Institutes of Health

Related topics

Related topics

10 relations
12p12Alzheimer's Disease Pathway KEGGERBB4 Signaling PathwayHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
A single, low dose of the NMDA receptor antagonist ketamine produces rapid antidepressant actions in treatment-resistant… 
Highly Cited
2010
Highly Cited
2010
Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?
Zinc transporter-3 (ZnT3) protein controls synaptic vesicular Zn2+ levels, which is predicted to regulate normal cognitive… 
Highly Cited
2008
Highly Cited
2008
Lamina-Specific Abnormalities of NMDA Receptor-Associated Postsynaptic Protein Transcripts in the Prefrontal Cortex in Schizophrenia and Bipolar Disorder
The hypothesis of N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia was initially based on observations that… 
Highly Cited
2007
Highly Cited
2007
Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
Highly Cited
2007
Highly Cited
2007
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
Highly Cited
2006
Highly Cited
2006
Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons.
Early in development, neurons only express NR1/NR2B-containing N-methyl-d-aspartate (NMDA) receptors. Later, NR2A subunits are… 
Highly Cited
2003
Highly Cited
2003
Impaired Long-Term Memory and NR2A-Type NMDA Receptor-Dependent Synaptic Plasticity in Mice Lacking c-Fos in the CNS
The immediate early gene c-fos is part of the activator protein-1 transcription factor and has been postulated to participate in… 
Review
2003
Review
2003
The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.
Highly Cited
2002
Highly Cited
2002
Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation
The therapeutic mechanisms of lithium for treating bipolar mood disorder remain poorly understood. Recent studies demonstrate… 
Highly Cited
1994
Highly Cited
1994
Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
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