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Metaplasticity: tuning synapses and networks for plasticity

  • W. Abraham
  • Biology
    Nature Reviews Neuroscience
  • 1 May 2008
TLDR
Various intercellular signalling molecules can trigger lasting changes in the ability of synapses to express plasticity; their mechanisms of action are reviewed here, along with a consideration of how metaplasticity might affect learning and clinical conditions.
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Metaplasticity: the plasticity of synaptic plasticity

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Long-term depression in hippocampus.

TLDR
The mechanisms of LTD are discussed and their possible relevance to hippocampal function is discussed.
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Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

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Metaplasticity: A new vista across the field of synaptic plasticity

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Induction and Experience-Dependent Consolidation of Stable Long-Term Potentiation Lasting Months in the Hippocampus

TLDR
It is reported that high-frequency stimulation paradigms applied to the rat dentate gyrus can elicit stable LTP lasting months and up to at least 1 year, and LTP can be shown to meet one of the principal criteria for a very long-term memory storage mechanism.
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A double dissociation within the hippocampus of dopamine D1/D5 receptor and β-adrenergic receptor contributions to the persistence of long-term potentiation

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Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

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Priming of long‐term potentiation induced by activation of metabotropic glutamate receptors coupled to phospholipase C

TLDR
MGluR priming of LTP results from biochemical cascades triggered by activation of phospholipase C coupled to group I mGluRs, and prior activation of muscarinic acetylcholine receptors produced at best a weak priming effect.
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Correlations between immediate early gene induction and the persistence of long-term potentiation

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