Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine

@inproceedings{Mao2009StabilityOS,
  title={Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine},
  author={Li-min Mao and Wei Wang and Xiang-Ping Chu and Guo-Chi Zhang and X Liu and Yuan-jian Yang and Michelle A Haines and Christopher J. Papasian and Eugene E. Fibuch and Shilpa Buch and Jian-guo Chen and John Q Wang},
  year={2009}
}
Plastic changes in glutamatergic synapses that lead to endurance of drug craving and addiction are poorly understood. We examined the turnover and trafficking of NMDA receptors and found that chronic exposure to the psychostimulant amphetamine (AMPH) induced selective downregulation of NMDA receptor NR2B subunits in the confined surface membrane pool of rat striatal neurons at synaptic sites. This downregulation was a long-lived event and was a result of the destabilization of surface-expressed… CONTINUE READING

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