Qiang Zhou

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NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Pierre Paoletti, Camilla Bellone, Qiang Zhou
Nature Reviews Neuroscience
2013

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal communication. NMDARs form tetrameric complexes that consist of several homologous subunits. The subunit… (More)

Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses

Qiang Zhou, Koichi J. Homma, Mu-Ming Poo
Neuron
2004

Activity-induced modification of neuronal connections is essential for the development of the nervous system and may also underlie learning and memory functions of mature brain. Previous studies have… (More)

Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior

Javier González-Maeso, Noelia V Weisstaub, +9 authors Jay A Gingrich
Neuron
2007

Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT(2A) receptor (2AR)… (More)

Synaptic Strength Regulated by Palmitate Cycling on PSD-95

Alaa El-Din El-Husseini, Eric Schnell, +7 authors David S. Bredt
Cell
2002

Dynamic regulation of AMPA-type glutamate receptors represents a primary mechanism for controlling synaptic strength, though mechanisms for this process are poorly understood. The palmitoylated… (More)

Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately.

Xiaobin Wang, Ozlem Bozdagi, Jessica S Nikitczuk, Zu Wei Zhai, Qiang Zhou, George W Huntley
Proceedings of the National Academy of Sciences…
2008

Persistent dendritic spine enlargement is associated with stable long-term potentiation (LTP), and the latter is thought to underlie long-lasting memories. Extracellular proteolytic remodeling of the… (More)

Spine expansion and stabilization associated with long-term potentiation.

Yunlei Yang, Xiaobin Wang, Matthew E. Frerking, Qiang Zhou
The Journal of neuroscience : the official…
2008

Stable expression of long-term synaptic plasticity is critical for the developmental refinement of neural circuits and for some forms of learning and memory. Although structural remodeling of… (More)

Kainate receptors depress excitatory synaptic transmission at CA3-->CA1 synapses in the hippocampus via a direct presynaptic action.

Matthew E. Frerking, Dietmar Schmitz, Qiang Zhou, Joshua P Johansen, Roger A Nicoll
The Journal of neuroscience : the official…
2001

Kainate receptor activation depresses synaptic release of neurotransmitter at a number of synapses in the CNS. The mechanism underlying this depression is controversial, and both ionotropic and… (More)

Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation.

Yunlei Yang, Xiaobin Wang, Matthew E. Frerking, Qiang Zhou
Proceedings of the National Academy of Sciences…
2008

Trafficking of AMPA subtype glutamate receptors (AMPARs) from intracellular compartments to synapses is thought to be a major mechanism underlying the expression of long-term potentiation (LTP), a… (More)

Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors

Ming Yue Xiao, Qiang Zhou, Roger A Nicoll
Neuropharmacology
2001

Electrophysiology, immunostaining and time lapse imaging techniques were employed to study the mechanism of long-term depression (LTD) induced by DHPG, a specific group I metabotropic glutamate… (More)

Contribution of cytoskeleton to the internalization of AMPA receptors.

Qiang Zhou, Minyi Xiao, Roger A Nicoll
Proceedings of the National Academy of Sciences…
2001

Trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) at synapses has been suggested to play an important role in the expression of synaptic plasticity.… (More)

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