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GLRX protein, human

Known as: Glutaredoxin, Glutaredoxin-1, GRX protein, human 
Glutaredoxin-1 (106 aa, ~12 kDa) is encoded by the human GLRX gene. This protein plays a role in the reduction of glutathione conjugates.
National Institutes of Health

Related topics

Related topics

8 relations
Enzyme GeneGLRX geneHomeostasisOxidation-Reduction

Broader (2)

Glutaredoxin 1glutaredoxin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Protein-thiol oxidation and cell death: regulatory role of glutaredoxins.
SIGNIFICANCE Glutaredoxin (Grx) is the primary enzyme responsible for catalysis of deglutathionylation of protein-mixed… 
Highly Cited
2011
Highly Cited
2011
Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary1
Oxidative stress has been implicated in various aspects of aging, but the role of oxidative stress in ovarian aging remains… 
Review
2008
Review
2008
Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes
Among the key antioxidant enzymes, thioredoxin and glutaredoxin systems play an important role in cell defense against oxidative… 
Highly Cited
2007
Highly Cited
2007
Glutathiolation Regulates Tumor Necrosis Factor-&agr;–Induced Caspase-3 Cleavage and Apoptosis: Key Role for Glutaredoxin in the Death Pathway
Caspase-3 cleavage and activation are known to play central roles in apoptosis. However, the mechanisms that regulate caspase-3… 
Highly Cited
2006
Highly Cited
2006
Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β
The transcription factor NF-κB, a central regulator of immunity, is subject to regulation by redox changes. We now report that… 
Highly Cited
2005
Highly Cited
2005
A Novel Monothiol Glutaredoxin (Grx4) from Escherichia coli Can Serve as a Substrate for Thioredoxin Reductase*
Glutaredoxins are ubiquitous proteins that catalyze the reduction of disulfides via reduced glutathione (GSH). Escherichia coli… 
Highly Cited
2003
Highly Cited
2003
Glutathione-Thiyl Radical Scavenging and Transferase Properties of Human Glutaredoxin (Thioltransferase)
Glutaredoxin (GRx, thioltransferase) is implicated in cellular redox regulation, and it is known for specific and efficient… 
Highly Cited
1998
Highly Cited
1998
Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor*
Stimulation of various cells with growth factors results in a transient increase in the intracellular concentration of H2O2 that… 
Review
1997
Review
1997
Selenium and the thioredoxin and glutaredoxin systems.
Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FAD-containing enzyme thioredoxin reductase (TR… 
Highly Cited
1994
Highly Cited
1994
Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.
Thioredoxin (Trx) and glutaredoxin (Grx1) are hydrogen donors for ribonucleotide reductase, the key enzyme for… 
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