• Publications
  • Influence
Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Some of the recent findings that illuminate the significance of redox signaling and exciting future perspectives are reviewed to highlight some of the current pitfalls and the approaches needed to advance this important area of biochemical and biomedical research. Expand
Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation*
Oxidative stress may cause tissue injury through activation of the precursors of matrix metalloproteinase (proMMPs). In this study, we observed glutathione (GSH)-dependent proMMP activation inducedExpand
Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β
The physiological relevance of the S-glutathionylation–GRX redox module in controlling the magnitude of activation of the NF-κB pathway is demonstrated. Expand
Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite
The results suggest that NO2−, at physiological or pathological levels, is a substrate for the mammalian peroxidases MPO and lactoperoxidase and that formation of NO2· via per oxidase-catalyzed oxidation ofNO2− may provide an additional pathway contributing to cytotoxicity or host defense associated with increased NO· production. Expand
Nitric oxide represses inhibitory κB kinase through S-nitrosylation
It is demonstrated here that S-nitrosothiols (SNO) caused a dose-dependent inhibition of the enzymatic activity of IKK, in lung epithelial cells and in Jurkat T cells, which was associated with S- Nitrosylation of the IKK complex, providing an additional mechanism for its antiinflammatory properties. Expand
Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation.
It is concluded that LA and DHLA have powerful antioxidant properties but can also exert pro-oxidant properties, both by its iron ion-reducing ability and probably by its ability to generate reactive sulphur-containing radicals that can damage certain proteins, such as alpha 1-antiproteinase and creatine kinase. Expand
Oxidants, antioxidants, and respiratory tract lining fluids.
The antioxidant composition of RTLFs and their role in modulating normal and pathophysiologic RTEC functions under conditions of oxidative stress are yet to be fully characterized. Expand
Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids.
It is demonstrated that ascorbate and urate are major low-molecular-mass ELF antioxidants in both the upper and lower respiratory tract, whereas GSH is present at significant concentrations only in bronchoalveolar ELF. Expand
ATP-mediated Activation of the NADPH Oxidase DUOX1 Mediates Airway Epithelial Responses to Bacterial Stimuli*
The results indicate that ATP-mediated DUOX1 activation represents a common response mechanism to several environmental stimuli, involving H2O2-dependent EGFR/ERK activation, ADAM17 activation, and EGFR ligand shedding, leading to amplified epithelial EGFR activation and IL-8 production. Expand