S. Kumar

Publications73
h-index27
Citations2,768
Highly Influential Citations92
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Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site*
The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production in vivo… Expand
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Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket*
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase compete with ATP for binding. Mutation of 23 residues in the ATP pocket indicated that several residues which affected binding… Expand
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Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.
The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with… Expand
  • 90
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Mice lacking NT‐3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells
Neurotrophin‐3 (NT‐3) and its receptor TrkC are known to be important for neuronal survival. More recently, NT‐3 has been implicated as playing a role in oligodendrocyte (OL) proliferation and… Expand
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Autophosphorylation of Type Iβ cGMP-dependent Protein Kinase Increases Basal Catalytic Activity and Enhances Allosteric Activation by cGMP or cAMP*
Autophosphorylation of purified bovine Iβ isozyme of cGMP-dependent protein kinase (Iβ cGK) in the presence of cGMP or cAMP increased basal kinase activity (−cGMP) as much as 4-fold and reduced the… Expand
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Comparative studies of the pigeon liver fatty acid synthetase complex and its subunits. Kinetics of partial reactions and the number of binding sites for acetyl and malonyl groups.
Abstract The fatty acid synthetase complex of pigeon liver has been dissociated (greater than 95%) into half-molecular weight subunits by dialyzing against Tris-glycine buffer, pH 8.3, containing 1… Expand
  • 105
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The NH2 terminus of retinal recoverin is acylated by a small family of fatty acids.
Recoverin is a recently identified Ca(2+)-binding protein that imparts Ca2+ sensitivity to vertebrate photoreceptor guanylate cyclase. In response to photo-induced depletion of intracellular cGMP and… Expand
  • 189
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Activity-based probes for protein tyrosine phosphatases.
Protein tyrosine phosphatases (PTPs) are involved in the regulation of many aspects of cellular activity including proliferation, differentiation, metabolism, migration, and survival. Given the large… Expand
  • 49
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Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex.
The type-II DNA-(cytosine-5)-methyltransferase M.HhaI was overexpressed in Escherichia coli and purified to apparent homogeneity. The purification scheme exploits a unique high salt back-extraction… Expand
  • 48
  • 2
Proteomic approaches to studying protein tyrosine phosphatases.
Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that play key roles in cell signaling. Deregulation of PTP activity results in aberrant tyrosine phosphorylation, which has… Expand
  • 35
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