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GCH1 gene

Known as: GTP CYCLOHYDROLASE I, GTPCH1, DYT5a 
 
National Institutes of Health

Papers overview

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2015
2015
Abstract Persistent postoperative pain is a well-established clinical problem with potential severe personal and socioeconomic… Expand
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2013
2013
Resistance to antimalarials targeting the folate pathway is widespread. GTP‐cyclohydrolase (gch1), the first enzyme in this… Expand
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2013
2013
GTP cyclohydrolase (GCH1) is the key‐enzyme to produce the essential enzyme cofactor, tetrahydrobiopterin. The byproduct… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial… Expand
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Highly Cited
2008
Highly Cited
2008
Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive… Expand
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Highly Cited
2007
Highly Cited
2007
C-reactive protein (CRP), a cardiovascular risk marker, induces endothelial dysfunction. We have previously shown that CRP… Expand
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2007
2007
BACKGROUND A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent… Expand
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2007
2007
We performed a systematic study on the frequency of point mutations and deletions of the gene GCH1 in dopa-responsive dystonia… Expand
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Highly Cited
1999
Highly Cited
1999
Dopamine-deficient mice (DA-/- ), lacking tyrosine hydroxylase (TH) in dopaminergic neurons, become hypoactive and aphagic and… Expand
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Highly Cited
1998
Highly Cited
1998
We performed a clinical and molecular genetic analysis in members of five families with dopa‐responsive dystonia. Four mutations… Expand
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