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Induction of plasticity in the human motor cortex by paired associative stimulation.
TLDR
It is proposed that the induced plasticity may represent a signature of associative long-term potentiation of cortical synapses or closely related neuronal mechanisms in the human cortex. Expand
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex.
TLDR
This study suggests that strict temporal Hebbian rules govern the induction of long-term potentiation/long-term depression-like phenomena in vivo in the human primary motor cortex. Expand
Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation
TLDR
Findings support the view that LTP‐like mechanisms may underlie the cortical plasticity induced by IPAS, as motor evoked potentials induced by unconditioned, single TMS pulses increased after IPAS. Expand
Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
TLDR
In vivo evidence of differential modulation of cortical inhibition by blockade of GABA uptake is provided, suggesting that presynaptic GABA autoreceptors may be involved in modulating cortical inhibition in the human motor cortex. Expand
Pallidal deep-brain stimulation in primary generalized or segmental dystonia.
TLDR
Bilateral pallidal neurostimulation for 3 months was more effective than sham stimulation in patients with primary generalized or segmental dystonia and sustained improvement in all movement symptoms, the level of disability, and quality of life, as compared with baseline scores. Expand
Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
TLDR
A high frequency of Fabry disease is shown in a cohort of patients with cryptogenic stroke, which corresponds to about 1.2% in young stroke patients, especially in those with the combination of infarction in the vertebrobasilar artery system and proteinuria. Expand
Cutaneomotor integration in humans is somatotopically organized at various levels of the nervous system and is task dependent
TLDR
The findings suggest that somatotopy of input-output relationships is implemented at both a spinal and a cortical level in the human central nervous system and may also depend on the motor task involved. Expand
Disturbance of sequential movements in patients with Parkinson's disease.
TLDR
The problems exhibited by patients with Parkinson's disease when they try to perform two rapid sequential movements can be seen as a deficit in the capacity to switch from one motor program to another within an overall motor plan. Expand
Timing‐dependent plasticity in human primary somatosensory cortex
TLDR
A simple model of modulation of excitability in human primary somatosensory cortex is suggested by mechanisms related to the spike‐timing‐dependent plasticity of neuronal synapses located in upper cortical layers. Expand
What is the optimal dose of botulinum toxin A in the treatment of cervical dystonia? Results of a double blind, placebo controlled, dose ranging study using Dysport®
TLDR
Magnitude and duration of improvement was greatest after injections of 1000 units Dysport®; however, at the cost of significantly more adverse events, therefore a lower starting dose of 500 units Dysports is recommended in patients with cervical dystonia, with upward titration at subsequent injection sessions if clinically necessary. Expand
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