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GTP Cyclohydrolase I

Known as: Cyclohydrolase I, GTP 
 
National Institutes of Health

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2 relations
GCH1 gene

Broader (1)

GTP Cyclohydrolase

Papers overview

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2019
2019
A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments.
BACKGROUND GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic… Expand
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2014
2014
Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches
We investigated whether polymorphisms of the endothelial nitric oxide synthase (eNOS), neuronal NOS (nNOS), and GTP… Expand
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2009
2009
Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells.
OBJECTIVE Estro-progestin treatments have been associated with an increased risk of thromboembolic events in postmenopausal women… Expand
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2005
2005
Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells.
We examined the effect of H(2)O(2) on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition… Expand
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2001
2001
Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter.
GTP cyclohydrolase I (GTPCH) gene expression was investigated in the human monoamine-containing neuroblastoma cell line SK-N-BE(2… Expand
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1999
1999
GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis.
Tetrahydrobiopterin, the coenzyme required for hydroxylation of phenylalanine, tyrosine, and tryptophan, regulates its own… Expand
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1999
1999
Dopa-responsive dystonia induced by a recessive GTP cyclohydrolase I mutation
Abstract. GTP cyclohydrolase I (GTPCH) catalyzes the rate-limiting step of tetrahydrobiopterin (BH4) biosynthesis. GTPCH has been… Expand
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1996
1996
Transient appearance of GTP cyclohydrolase I — positive non-monoaminergic neurons in the ventral lateral geniculate nucleus of postnatal mice
The transient appearance of GTP cyclohydrolase I (GCH)-immunoreactive (ir) cells in the ventral lateral geniculate nuclear region… Expand
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1993
1993
Expression of GTP cyclohydrolase I (GTPCH) mRNA in the rat: tissue distribution and effect of reserpine.
Disruption of vesicular monoamine storage by reserpine results in a marked depletion of monoamines in the central and peripheral… Expand
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1993
1993
Localization of GTP cyclohydrolase I (GTPCH) mRNA in the rat brain by in situ hybridization.
GTP cyclohydrolase I (GTPCH) is the first and rate-limiting enzyme in the tetrahydrobiopterin (BH4) biosynthetic pathway. BH4 is… Expand
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