GTP Cyclohydrolase

Known as: GTP 7,8-8,9-dihydrolase, 8-Formylhydrolase, GTP, Cyclohydrolase, GTP 
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring… (More)
National Institutes of Health

Papers overview

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2014
2014
GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine production in nigrostriatal cells. Loss-of… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The activation of AMP-activated protein kinase (AMPK) has been reported to improve endothelial function. However, the… (More)
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Highly Cited
2006
Highly Cited
2006
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of… (More)
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Highly Cited
2005
Highly Cited
2005
Endothelial dysfunction in vascular disease states is associated with reduced NO bioactivity and increased superoxide (O2… (More)
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Highly Cited
2002
Highly Cited
2002
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVES Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) activity. BH4 levels… (More)
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Review
2000
Review
2000
Tetrahydrobiopterin (BH(4)) cofactor is essential for various processes, and is present in probably every cell or tissue of… (More)
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1995
1995
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we… (More)
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Highly Cited
1994
Highly Cited
1994
Hereditary progressive dystonia with marked diurnal fluctuation (HPD) (also known as dopa responsive dystonia) is a dystonia with… (More)
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Highly Cited
1988
Highly Cited
1988
The determination and characterization of a cannabinoid receptor from brain are reported. A biologically active bicyclic… (More)
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