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GANT 61

Known as: GANT-61, GANT61 
National Institutes of Health

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PyridinesPyrimidines

Papers overview

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2019
2019
GANT61 alleviates arthritic symptoms by targeting fibroblast-like synoviocytes in CIA rats.
2017
2017
[Effect of Hedgehog Signaling Pathway Abnormality on Chemothe-rapeutic Resistance of Multiple Myeloma].
OBJECTIVE To study the correlation between the excessive activation of Hedgehog signal and the drug resistance of multiple… 
2017
2017
Hedgehog signaling inhibitor GANT61 induces endoplasmic reticulum stress-mediated protective autophagy in hepatic stellate cells.
2017
2017
Hedgehog signaling is activated in canine transitional cell carcinoma and contributes to cell proliferation and survival
Transitional cell carcinoma (TCC) is the most commonly diagnosed tumor of the canine urinary system. Hedgehog (HH) signaling… 
2016
2016
GLI1 inhibitor GANT61 exhibits antitumor efficacy in T-cell lymphoma cells through down-regulation of p-STAT3 and SOCS3
T-cell lymphomas are lymphoid malignancies with aggressive clinical course and poor prognosis. Increasing evidences suggest that… 
2015
2015
ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: identification of novel targets for concerted therapy concepts.
2014
2014
Activated hedgehog pathway is a potential target for pharmacological intervention in biliary tract cancer
Hedgehog (Hh) signalling contributes to carcinogenesis and represents a valid druggable target in human cancers, possibly also in… 
2014
2014
Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents
Cancer-related death is one of the most common causes of mortality in society. Small molecules have the capability to disrupt… 
Highly Cited
2013
Highly Cited
2013
Noncanonical Regulation of the Hedgehog Mediator GLI1 by c-MYC in Burkitt Lymphoma
Although Hedgehog signaling plays a major role in GLI1 transcription, there is now evidence suggesting that other pathways/genes… 
2012
2012
Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine.
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