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GAB1 gene

Known as: GRB2-Associated Binding Protein 1 Gene, GRB2-ASSOCIATED BINDING PROTEIN 1, GRB2 associated binding protein 1 
This gene is involved in intracellular signaling.
National Institutes of Health

Related topics

Related topics

3 relations
GAB1 protein, humanGRB2-Associated-Binding Protein 1Signal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Concerted Functions of Gab1 and Shp2 in Liver Regeneration and Hepatoprotection
ABSTRACT Liver regeneration is a rapid and concerted response to injury, in which growth factor-generated intracellular signals… 
Highly Cited
2005
Highly Cited
2005
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.
Long-range migrating progenitor cells generate hypaxial muscle, for instance the muscle of the limbs, hypoglossal cord, and… 
Highly Cited
2004
Highly Cited
2004
Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor*
Epidermal growth factor (EGF) induces paxillin tyrosine dephosphorylation and Src activation, but the signaling pathways that… 
Highly Cited
2004
Highly Cited
2004
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
BackgroundGab1 is a docking protein that recruits phosphatidylinositol-3 kinase (PI-3 kinase) and other effector proteins in… 
Highly Cited
2002
Highly Cited
2002
Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2
ABSTRACT Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals… 
Highly Cited
2002
Highly Cited
2002
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression.
Insulin-like growth factor (IGF)-1 and the type I IGF-1 receptor are important regulators of vascular function that may… 
Highly Cited
2000
Highly Cited
2000
Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation
ABSTRACT Gab1 is a member of the Gab/DOS (Daughter of Sevenless) family of adapter molecules, which contain a pleckstrin homology… 
Highly Cited
2000
Highly Cited
2000
Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases*
The Gab family of docking proteins is phosphorylated in response to various growth factors and cytokines and serves to recruit… 
Highly Cited
2000
Highly Cited
2000
A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling
ABSTRACT The Gab1 protein is tyrosine phosphorylated in response to various growth factors and serves as a docking protein that… 
Highly Cited
1998
Highly Cited
1998
The Gab1 Protein Is a Docking Site for Multiple Proteins Involved in Signaling by the B Cell Antigen Receptor*
Gab1 is a member of the docking/scaffolding protein family which includes IRS-1, IRS-2, c-Cbl, p130 cas , and p62 dok . These… 
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