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A Grb2-associated docking protein in EGF- and insulin-receptor signalling
THE protein Grb2 plays a central role in signalling by receptor protein-tyrosine kinases1,2, where its SH2 domain binds to the receptor and its two SH3 domains link to effectors. One target effectorExpand
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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.
Primary malignant gliomas from 63 patients were analyzed to determine the relationship between amplification of the gene encoding the epidermal growth factor receptor (EGFR) and expression of theExpand
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The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase
ABSTRACT Stimulation of the hepatocyte growth factor (HGF) receptor tyrosine kinase, Met, induces mitogenesis, motility, invasion, and branching tubulogenesis of epithelial and endothelial cell linesExpand
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Identification of an amplified, highly expressed gene in a human glioma.
A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located atExpand
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Structural alterations of the epidermal growth factor receptor gene in human gliomas.
The epidermal growth factor receptor (EGFR) gene is amplified in 40% of malignant gliomas, and the amplified genes are frequently rearranged. We have characterized the genetic alterations associatedExpand
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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
CD44 is a widely distributed cell surface adhesion molecule and is implicated in diverse biological processes. However, the nature of intracellular signaling triggered by CD44 remains to beExpand
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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.
Nerve growth factor (NGF) prevents apoptosis through stimulation of the TrkA receptor protein tyrosine kinase. The downstream activation of phosphatidylinositol 3-kinase (PI 3-kinase) is essentialExpand
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The GLI-Kruppel family of human genes.
Previous characterization of GLI, a gene found to be amplified and expressed in a subset of human brain tumors, revealed the presence of five tandem zinc fingers related to those of Krüppel (Kr), aExpand
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A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the Gab1 Docking Protein Is Required for Epithelial Morphogenesis*
Stimulation of the hepatocyte growth factor receptor tyrosine kinase, Met, induces the inherent morphogenic program of epithelial cells. The multisubstrate binding protein Gab1 (Grb2-associatedExpand
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Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor*
The most frequently found alteration of the epidermal growth factor receptor (EGFR) in human tumors is a deletion of exons 2–7. This receptor, termed EGFRvIII, can transform NIH 3T3 cells, and theExpand
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