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Freeze Drying

Known as: Lyophilizations, Freeze-drying, Dryings, Freeze 
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Biologic Preservation
Desiccationstandards characteristics

Papers overview

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Highly Cited
2008
Highly Cited
2008
Effects of Various Sugars Added to Growth and Drying Media upon Thermotolerance and Survival throughout Storage of Freeze‐Dried lactobacillus delbrueckii ssp. bulgaricus
The aim of this research effort was to investigate the role of various sugar substrates in the growth medium upon thermotolerance… 
Highly Cited
2000
Highly Cited
2000
Influence of different parameters on reconstitution of lyophilized SLN.
Highly Cited
1996
Highly Cited
1996
Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states.
Maintaining a native-like structure of protein pharmaceuticals during lyophilization is an important aspect of formulation… 
Highly Cited
1993
Highly Cited
1993
Dramatic enhancement of enzymatic activity in organic solvents by lyoprotectants
When seven different hydrolytic enzymes (four proteases and three lipases) were lyophilized from aqueous solution containing a… 
Highly Cited
1990
Highly Cited
1990
Design and synthesis of a peptide having chymotrypsin-like esterase activity.
A peptide having enzyme-like catalytic activity has been designed and synthesized. Computer modeling was used to design a bundle… 
Highly Cited
1982
Highly Cited
1982
Modification of beet and cabbage diets of aflatoxin B1-induced rat plasma alpha-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine.
Highly Cited
1981
Highly Cited
1981
Identification and mass analysis of human fibrinogen molecules and their domains by scanning transmission electron microscopy.
Highly Cited
1979
Highly Cited
1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10… 
Highly Cited
1971
Highly Cited
1971
Proteins coupled to polyacrylamide beads using glutaraldehyde.
Highly Cited
1966
Highly Cited
1966
HIGH RESOLUTION AUTORADIOGRAPHY WITH DRY MOUNTED, FREEZE-DRIED FROZEN SECTIONS COMPARATIVE STUDY OF SIX METHODS USING TWO DIFFUSIBLE COMPOUNDS H-ESTRADIOL AND H-MESOBILIRUBINOGEN
Localization of two soluble compounds, 3H-estradiol in liver and uterus and 3H-mesobilirubinogen in liver, has been studied by… 
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