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Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells.
Since macrophages constitute the major site of liposome localization after parenteral administration and play an important role in the control of the immune system, cationic liposomes should be used with caution to deliver gene or antisense oligonucleotide to mammalian cells.
Solid lipid nanoparticles as drug carriers. I. Incorporation and retention of the lipophilic prodrug 3′-azido-3′-deoxythymidine palmitate
Abstract Solid lipid nanoparticles (SLN) were prepared with trilaurin (TL) as the SLN solid core and dipalmitoylphosphatidylcholine (DPPC) or a mixture of DPPC and dimyristoylphosphatidylglycerol…
Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells
- M. Filion, P. Lépicier, A. Morales, N. Phillips
- Biology, MedicineBritish Journal of Cancer
- 1 January 1999
The results indicate that MCC directly effects bladder cancer cells by inhibiting cellular proliferation through the induction of apoptosis, and has the potential for an indirect anti-cancer activity by stimulating cancer-infiltrating monocytes/macrophages to synthesize IL-12.
Liposomal encapsulation of azidothymidine results in decreased hematopoietic toxicity and enhanced activity against murine acquired immunodeficiency syndrome.
The results indicate that AZT-induced hematopoietic toxicity may not be a limiting factor for antiviral therapy, and that the use of liposomes to deliver AZT results in enhanced antiretroviral activity in mice.
Enhanced antibody response to liposome-associated protein antigens: preferential stimulation of IgG2a/b production.
Results demonstrate that, whereas MDP preferentially stimulates IgG1 antibodies, liposomes elicit high levels of IgG2a/2b isotypes with significantly longer serum half-lives, especially when MDP-GDP was present in the liposome.
Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization.
It is demonstrated that SLNs containing AZT-P can be autoclaved, lyophilized and reconstituted without significant changes in SLN diameter and zeta potential or in the quantity of incorporated prodrug.
Influence of Surface Properties at Biodegradable Microsphere Surfaces: Effects on Plasma Protein Adsorption and Phagocytosis
- F. Lacasse, M. Filion, N. Phillips, E. Escher, J. N. Mcmullen, P. Hildgen
- Chemistry, MedicinePharmaceutical Research
- 1 February 1998
These results demonstrate that spray-dried PEG-containing microspheres can be manufactured and that an appropriate concentration of this excipient in microsphere results in decreased phagocytosis.
Liposomal encapsulation of 3'-azido-3'-deoxythymidine (AZT) results in decreased bone marrow toxicity and enhanced activity against murine AIDS-induced immunosuppression.
Liposomal encapsulation of AZT enhanced localization in the liver, spleen, and lung, and reduced localization in bone marrow, and resulted in normal T- and B-cell mitogenic responses at both 4 and 7 weeks postinfection.
Pro‐inflammatory activity of contaminating DNA in hyaluronic acid preparations
It is clear from this study that HA preparations can induce the synthesis of pro‐inflammatory cytokines by monocytes, and the presence of pro-inflammatory DNA in HA preparations should be evaluated before its use, not only for the treatment of patients with inflammatory disorders, but also before many other applications.
Activation of alveolar macrophage tumoricidal activity and eradication of experimental metastases by freeze-dried liposomes containing a new lipophilic muramyl dipeptide derivative.
Evidence is provided that this class of lipophilic MDP derivative, when incorporated into freeze-dried liposomes, is a potent inducer of macrophage cytotoxic activity in vitro and in situ, and has antitumor activity in vivo.