R. Simpson

Publications847
h-index100
Citations46,801
Highly Influential Citations1,644
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Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
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Exosomes: extracellular organelles important in intercellular communication.
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Style self-incompatibility gene products of Nicotlana alata are ribonucleases
TLDR
It is reported here that glycoproteins corresponding to the S1, S2, S3, S6 and S7 alleles isolated from style extracts of N. alata6 are ribonucleases, which implicate ribonuclease activity in the mechanism of gametophytic self-incompatibility.
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Plant and microbial strategies to improve the phosphorus efficiency of agriculture
TLDR
Evidence that more P-efficient plants can be developed by modifying root growth and architecture, through manipulation of root exudates or by managing plant-microbial associations such as arbuscular mycorrhizal fungi and microbial inoculants is critically reviewed.
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HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*
TLDR
HtrA2 can, like DIABLO/Smac, prevent XIAP inhibition of active caspase 3in vitro and is able to counteract XIAP protection of mammalian NT2 cells against UV-induced cell death.
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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
TLDR
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles that aims to provide a single authoritative source for information on vesicle structure and function.
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Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.
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ExoCarta 2012: database of exosomal proteins, RNA and lipids
TLDR
This work believes that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and trigger new exosomal studies.
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Soil Microorganisms Mediating Phosphorus Availability Update on Microbial Phosphorus
Microorganisms are integral to the soil phosphorus (P) cycle and as such play an important role in mediating the availability of P to plants. Understanding the microbial contribution to plant P…
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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
TLDR
It appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway, analogous to the family of F-box-containing proteins.
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