R. Simpson

Publications565
h-index91
Citations38,946
Highly Influential Citations1,357
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Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we used coimmuno-precipitation and 2D immobilized pH gradient/SDS PAGE, followed by electrospray ionization tandem… Expand
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An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron
The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays adaptive responses to iron status. We have… Expand
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Exosomes: extracellular organelles important in intercellular communication.
In addition to intracellular organelles, eukaryotic cells also contain extracellular organelles that are released, or shed, into the microenvironment. These membranous extracellular organelles… Expand
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Style self-incompatibility gene products of Nicotlana alata are ribonucleases
SELF-INCOMPATIBILITY in flowering plants is often controlled by a single nuclear gene (the S-gene) having several alleles1. This gene prevents fertilization by self-pollen or by pollen bearing either… Expand
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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
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HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP antagonists, insect Grim, HID, and Reaper and mammalian DIABLO/Smac. We now demonstrate that HtrA2, a mammalian… Expand
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Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase*
Central infusion of angiotensin IV or its more stable analogues facilitates memory retention and retrieval in normal animals and reverses amnesia induced by scopolamine or by bilateral perforant… Expand
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FunRich: An open access standalone functional enrichment and interaction network analysis tool
TLDR
We present FunRich, an open access, standalone functional enrichment and network analysis tool that can be used to perform functional enrichment analysis on background databases that are integrated from heterogeneous genomic and proteomic resources. Expand
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Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.
Exosomes are 40-100nm extracellular vesicles that are released from a multitude of cell types, and perform diverse cellular functions including intercellular communication, antigen presentation, and… Expand
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ExoCarta: A compendium of exosomal proteins and RNA
Exosomes, membrane microvesicles (40–100 nm) secreted by most cell types, can be isolated in several ways while characterizing them is heavily based on electron microscopy and, most importantly, the… Expand
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