FAQ

Free Fatty Acid Receptor 1

Known as: G-Protein Coupled Receptor 40 
Free fatty acid receptor 1 (300 aa, ~31 kDa) is encoded by the human FFAR1 gene. This protein plays a role in fatty acid-dependent receptor signaling… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
01220052017

Related topics

Related topics

14 relations
Energy MetabolismFFAR1 geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Signaling
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Free Fatty Acid Receptor 1
Plasma membrane
Signal Transduction
Energy Metabolism
Structure of beta Cell of islet
Receptors, Cell Surface

Papers overview

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Review
2018
Review
2018
Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.
The free fatty acid receptor 1 (FFAR1/GPR40) amplifies glucose-dependent insulin secretion; therefore, it has attracted… (More)
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Review
2017
Review
2017
Ligands at Free Fatty Acid Receptor 1 (GPR40).
FFA1 is a G protein-coupled receptor activated by medium- to long-chain fatty acids. FFA1 plays important roles in various… (More)
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2017
2017
Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury
Fasiglifam (TAK-875), a Free Fatty Acid Receptor 1 (FFAR1) agonist in development for the treatment of type 2 diabetes, was… (More)
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2016
2016
Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.
The free fatty acid receptor 1 (FFA1/GPR40) is a potential target for treatment of type 2 diabetes. Although several potent… (More)
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2015
2015
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
FFAR1/GPR40 is a seven-transmembrane domain receptor (7TMR) expressed in pancreatic β cells and activated by FFAs… (More)
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2015
2015
Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain.
BACKGROUND/AIMS Conjugated linoleic acids (CLAs) affect body fat distribution, induce insulin resistance and stimulate insulin… (More)
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2014
2014
Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans
Genetic variation in FFAR1 modulates insulin secretion dependent on non-esterified fatty acid (NEFA) concentrations. We… (More)
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2013
2013
Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently… (More)
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2005
2005
Free Fatty Acid Receptor 1 (FFA1R/GPR40) and Its Involvement in FA Stimulated Insulin Secretion
" Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion " Use of alternative… (More)
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