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Free Fatty Acid Receptor 1

Known as: G-Protein Coupled Receptor 40 
Free fatty acid receptor 1 (300 aa, ~31 kDa) is encoded by the human FFAR1 gene. This protein plays a role in fatty acid-dependent receptor signaling… 
National Institutes of Health

Related topics

Related topics

14 relations
Energy MetabolismFFAR1 geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Perturbation of the lipid metabolism and intestinal inflammation in growing pigs with low birth weight is associated with the alterations of gut microbiota.
2019
2019
Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5
Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with… 
Review
2019
Review
2019
Obesity-induced asthma: Role of free fatty acid receptors
2016
2016
Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.
The free fatty acid receptor 1 (FFA1/GPR40) is a potential target for treatment of type 2 diabetes. Although several potent… 
Review
2016
Review
2016
Ligands at Free Fatty Acid Receptor 1 (GPR40).
  • Takafumi Hara
  • Handbook of Experimental Pharmacology
  • 2016
  • Corpus ID: 31422900
FFA1 is a G protein-coupled receptor activated by medium- to long-chain fatty acids. FFA1 plays important roles in various… 
Highly Cited
2015
Highly Cited
2015
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1*
Background: FFAR1/GPR40 is a potential target to enhance insulin secretion in type 2 diabetes, yet knowledge of the… 
2014
2014
The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells.
Highly Cited
2009
Highly Cited
2009
The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1*♦
The endogenous ligands for free fatty acid receptor 1 (FFA1) are medium and longer chain free fatty acids. However, a range of… 
Highly Cited
2005
Highly Cited
2005
Free fatty acid receptor 1 (FFA1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion
Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism… 
Highly Cited
2005
Highly Cited
2005
Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.
Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism… 
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