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Free Fatty Acid Receptor 1

Known as: G-Protein Coupled Receptor 40 
Free fatty acid receptor 1 (300 aa, ~31 kDa) is encoded by the human FFAR1 gene. This protein plays a role in fatty acid-dependent receptor signaling… Expand
National Institutes of Health

Related topics

Related topics

14 relations
Energy MetabolismFFAR1 geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Signaling
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Papers overview

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2018
2018
Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold.
The free fatty acid receptor 1 (FFA1) plays an important role in amplifying insulin secretion in a glucose dependent manner. We… Expand
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2017
2017
Design, synthesis and structure-activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker.
The free fatty acid receptor 1 (FFA1/GPR40) has attracted extensive attention as a novel antidiabetic target. Aiming to explore… Expand
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2016
2016
Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.
The free fatty acid receptor 1 (FFA1/GPR40) is a potential target for treatment of type 2 diabetes. Although several potent… Expand
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2016
2016
Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold.
Free fatty acid receptor 1 (FFA1), previously known as GPR40 is a G protein-coupled receptor and a new target for treatment of… Expand
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2015
2015
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1*
Background: FFAR1/GPR40 is a potential target to enhance insulin secretion in type 2 diabetes, yet knowledge of the… Expand
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2015
2015
Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.
Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in… Expand
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2015
2015
Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.
The free fatty acid receptor 1 (FFA1) is a novel antidiabetic target for the treatment of type 2 diabetes based on particular… Expand
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Highly Cited
2009
Highly Cited
2009
The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1*♦
The endogenous ligands for free fatty acid receptor 1 (FFA1) are medium and longer chain free fatty acids. However, a range of… Expand
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Highly Cited
2005
Highly Cited
2005
Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.
Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism… Expand
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2005
2005
Free fatty acid receptor 1 (FFA1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion
Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism… Expand
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