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Free Fatty Acid Receptor 1
Known as:
G-Protein Coupled Receptor 40
Free fatty acid receptor 1 (300 aa, ~31 kDa) is encoded by the human FFAR1 gene. This protein plays a role in fatty acid-dependent receptor signaling…
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National Institutes of Health
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Related topics
Related topics
14 relations
Energy Metabolism
FFAR1 gene
G Protein-Coupled Receptor Genes
G Protein-Coupled Receptor Signaling
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Perturbation of the lipid metabolism and intestinal inflammation in growing pigs with low birth weight is associated with the alterations of gut microbiota.
Shimeng Huang
,
Zhenhua Wu
,
+6 authors
Jun-Jun Wang
Science of the Total Environment
2020
Corpus ID: 211725708
2019
2019
Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5
M. P. Hernández-Cáceres
,
Lilian Toledo-Valenzuela
,
+11 authors
E. Morselli
Frontiers in Endocrinology
2019
Corpus ID: 85495118
Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with…
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Review
2019
Review
2019
Obesity-induced asthma: Role of free fatty acid receptors
K. Mizuta
,
Atsuko Matoba
,
S. Shibata
,
E. Masaki
,
Charles W. Emala Sr
Japanese Dental Science Review
2019
Corpus ID: 202559304
2017
2017
Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4
K. Watterson
,
Steffen V. F. Hansen
,
+8 authors
G. Milligan
Molecular Pharmacology
2017
Corpus ID: 21621352
High-affinity and selective antagonists that are able to block the actions of both endogenous and synthetic agonists of G protein…
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Review
2016
Review
2016
Ligands at Free Fatty Acid Receptor 1 (GPR40).
Takafumi Hara
Handbook of Experimental Pharmacology
2016
Corpus ID: 31422900
FFA1 is a G protein-coupled receptor activated by medium- to long-chain fatty acids. FFA1 plays important roles in various…
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Highly Cited
2015
Highly Cited
2015
β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1*
A. Mancini
,
G. Bertrand
,
+5 authors
V. Poitout
Journal of Biological Chemistry
2015
Corpus ID: 22504650
Background: FFAR1/GPR40 is a potential target to enhance insulin secretion in type 2 diabetes, yet knowledge of the…
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2014
2014
The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells.
Ximei Shen
,
Liyong Yang
,
+4 authors
Xiuhui Cai
Metabolism: Clinical and Experimental
2014
Corpus ID: 25736309
2014
2014
Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation.
M. Helal
,
K. Darwish
,
M. Hammad
Bioorganic & Medicinal Chemistry Letters
2014
Corpus ID: 25786770
Highly Cited
2009
Highly Cited
2009
The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1*♦
N. J. Smith
,
Leigh A. Stoddart
,
Nicola M. Devine
,
Laura Jenkins
,
G. Milligan
Journal of Biological Chemistry
2009
Corpus ID: 41733679
The endogenous ligands for free fatty acid receptor 1 (FFA1) are medium and longer chain free fatty acids. However, a range of…
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Highly Cited
2005
Highly Cited
2005
Free fatty acid receptor 1 (FFA1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion
Albert Salehi
,
E. Flodgren
,
+4 authors
Björn Olde
Cell and Tissue Research
2005
Corpus ID: 10272486
Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism…
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